Research Highlight |
Featured
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In Brief |
Ofatumumab is effective in elderly patients
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Review Article |
Delirium in patients with cancer: assessment, impact, mechanisms and management
Delirium is a common neurocognitive manifestation in patients with cancer, particularly at advanced stages of the disease, and represents a considerable challenge for the patients, their families as well as health-care professionals involved in their care. This Review provides a comprehensive overview of the diagnosis, assessment, pathogenesis and management of delirium. The experiential impacts of delirium on patients with the condition, their family members and health-care practitioners are also discussed.
- Peter G. Lawlor
- & Shirley H. Bush
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Review Article |
Challenges of managing elderly men with prostate cancer
Men who are elderly constitute a unique patient group who are often denied effective treatments for fear of toxicity or diminished efficacy or are unduly subjected to intense therapies despite multiple comorbidities and indolent disease. This Review highlights the importance of individualizing therapy based on the comorbidities, functional status, nutritional status and aggressiveness of disease rather than age alone.
- Gautam G. Jha
- , Vidhu Anand
- & Badrinath R. Konety
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Perspectives |
Emerging developments of chemoradiotherapy in stage III NSCLC
Many patients who present with stage III NSCLC are in their 70s with multiple comorbidities who are generally unfit to receive the standard chemoradiotherapy regimen. In this Perspectives article, the author puts forth proposals to advance research within shorter timescales to improve outcomes for patients for whom standard treatment is unavailable.
- Allan Price
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Review Article |
Geriatric oncology research to improve clinical care
The needs and treatment requirements of older patients with cancer are different to their younger counterparts. However, few data are available on which to base important clinical decisions for the treatment of this patient population. This Review article outlines the issues and some of the solutions associated with treating cancer in older patients and uses three case studies to illustrate the practical problems that clinicians face.
- Supriya Mohile
- , William Dale
- & Arti Hurria
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News & Views |
Locally advanced NCSLC in the elderly: which treatment?
Treatment of locally advanced non-small-cell lung cancer (NSCLC) in the elderly is challenging, with many available treatment options from radiotherapy alone to sequential chemoradiation. The latest phase III trial comparing radiotherapy alone with concurrent chemoradiation reported a survival improvement for the combination; however, this does not define a new standard treatment.
- Cesare Gridelli
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News & Views |
Advanced NSCLC—should we use doublets in elderly patients?
Elderly patients have often been excluded from, or under represented in, clinical trials. Now, a phase III trial has demonstrated that a platinum-based doublet regimen provides superior outcomes in elderly patients with advanced-stage non-small-cell lung cancer, and should be considered for palliative chemotherapy in this group of patients.
- Robert Pirker
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Research Highlight |
Reduced-intensity induction therapy for elderly patients with multiple myeloma
- Lisa Richards
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Review Article |
Epidemiology and treatment of melanoma in elderly patients
Melanoma is an increasing problem, especially in the elderly population. In this article, the authors highlight key aspects of the epidemiology, presentation, staging and management of melanoma. They also emphasize the need for greater understanding and awareness of this cancer to optimize patient outcomes.
- Susan Tsai
- , Charles Balch
- & Julie Lange
New first-line options in CLL
Alliance to iLLUMINATE the chemo-free sign
Sunitinib has similar efficacy irrespective of age in mRCC
Will you still fit me when I'm seventy-four?
Questionnaire developed specifically for older people with cancer