Genome informatics

Definition

Genome informatics is the field in which computer and statistical techniques are applied to derive biological information from genome sequences. Genome informatics includes methods to analyse DNA sequence information and to predict protein sequence and structure.

Latest Research and Reviews

News and Comment

  • News and Views |

    A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

    • Dashiell J Massey
    •  & Amnon Koren
    Nature Genetics 49, 1673–1674
  • Editorial |

    A solution to screening for recessive heritable disorders and identifying genetic influences on common diseases is to be found in the history of one of the world's most populous regions. Large South Asian populations are a mosaic of smaller populations, many of which have founder effects as extreme as those in the European isolates that first inspired genetic medicine.

  • News and Views |

    The sequencing and draft assembly of the sweet potato genome has resolved much of its complex genetic redundancies, allowing a better inference of the botanical origin of the staple crop.

    • Haibao Tang
    Nature Plants 3, 688–689
  • News |

    PCR duplicates—sequencing reads from the same original genomic fragment—can cause headaches. But there are remedies.

    • Vivien Marx
    Nature Methods 14, 473–476