Genetic models

  • Article
    | Open Access

    Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that express PA-Cre 3.0 conditionally.

    • Kumi Morikawa
    • , Kazuhiro Furuhashi
    •  & Masayuki Yazawa
  • Article
    | Open Access

    Individuals with Down Syndrome have hematopoietic abnormalities including high risk of leukaemia. Here the authors show that transcriptional silencing of one chromosome 21 by XIST effectively corrects cell function and development to prevent excessive production of megakaryocytes and erythroids, shown during hematopoietic differentiation of human iPSCs in culture.

    • Jen-Chieh Chiang
    • , Jun Jiang
    •  & Jeanne B. Lawrence
  • Article
    | Open Access

    The domestic dog is an important model organism for our understanding of cancer and other diseases. Here the authors conduct a genome-wide association study across multiple breeds and identify novel loci significantly associated with several complex diseases and morphological traits.

    • Jessica J. Hayward
    • , Marta G. Castelhano
    •  & Adam R. Boyko