Fragile sites articles within Nature Communications

Featured

  • Article
    | Open Access

    Profiling of human DNA polymerase Polε and Polα demonstrates their roles in leading and lagging strand DNA synthesis, and their independent measures allowed accurate predictions of replication dynamics and effects of transcription.

    • Eri Koyanagi
    • , Yoko Kakimoto
    •  & Yasukazu Daigaku

  • Article
    | Open Access

    BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.

    • Jekaterina Vohhodina
    • , Liana J. Goehring
    •  & David M. Livingston

  • Article
    | Open Access

    Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.

    • Dan Sarni
    • , Takayo Sasaki
    •  & Batsheva Kerem

  • Article
    | Open Access

    Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.

    • Olivier Brison
    • , Sami El-Hilali
    •  & Chun-Long Chen

  • Article
    | Open Access

    TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.

    • Kate Beishline
    • , Olga Vladimirova
    •  & Paul M. Lieberman

  • Article
    | Open Access

    The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in promoting DNA replication and suppressing R-loop mediated DNA damage at tRNA genes.

    • Phong Lan Thao Tran
    • , Thomas J. Pohl
    •  & Virginia A. Zakian

  • Article
    | Open Access

    Translesion synthesis polymerase eta has a well characterized role in replicating past UV-induced DNA lesions and has recently been shown to act at difficult to replicate sequences. Here the authors show that its SUMOylation is required to recruit pol eta at the replication fork and to prevent under-replicated DNA.

    • Emmanuelle Despras
    • , Méghane Sittewelle
    •  & Patricia L Kannouche

  • Article |

    Aberrant oncogene expression can cause replication stress leading to chromosomal breaks. Here the authors map the chromosomal break loci induced by two different oncogenes and by a replication inhibitor, and show that each treatment induces a unique pattern of breaks in the same cell type.

    • Karin Miron
    • , Tamar Golan-Lev
    •  & Batsheva Kerem

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