Fragile sites articles within Nature

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• Article | 12 April 2023

  Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats

  Epstein–Barr Virus (EBV) nuclear antigen 1 is shown to induce breakage of a fragile site on chromosome 11 by binding to a cluster of EBV-like imperfect palindromic repeats.

  • Julia Su Zhou Li
  • , Ammal Abbasi
  •  & Don W. Cleveland

• Letter | 02 December 2015

  Replication stress activates DNA repair synthesis in mitosis

  Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

  • Sheroy Minocherhomji
  • , Songmin Ying
  •  & Ian D. Hickson

• News & Views | 02 February 2011

  DNA fragility put into context

  Fragile sites are genomic regions prone to deletions or other alterations during DNA replication. The reason for the susceptibility of these sites to damage may be simple: they contain few replication initiation sites. See Letter p.120

  • Kay Huebner