Fracture repair articles within Nature Communications

Featured

  • Article
    | Open Access

    Critical-sized bone defects still present clinical challenges. Here the authors show that transplantation of neurotrophic supplement-incorporated hydrogel grafts promote full-thickness regeneration of the calvarium and perform scRNA-seq to reveal contributing stem/progenitor cells, notably a resident Msx1+ skeletal stem cell population.

    • Xianzhu Zhang
    • , Wei Jiang
    •  & Hongwei Ouyang

  • Article
    | Open Access

    Biodegradable implants are of great interest in orthopaedic applications but have been limited by low mechanical strength. Here, the authors examine systematically in detail the strengthening of biodegradable zinc by alloying with beneficial elements using mechanical, biodegradability and biocompatibility testing.

    • Hongtao Yang
    • , Bo Jia
    •  & Yufeng Zheng

  • Article
    | Open Access

    Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates.

    • Monica Florio
    • , Kannan Gunasekaran
    •  & Michael S. Ominsky

  • Article
    | Open Access

    γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.

    • Takehito Ono
    • , Kazuo Okamoto
    •  & Hiroshi Takayanagi

Browse broader subjects

Browse Fracture repair across other nature.com journals