Foam cells articles within Nature Communications

Featured

• Article
  05 February 2024 | Open Access

  Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease

  Specialized pro-resolving mediators (SPM) are involved in the reprogramming of immune responses. Here the authors show that resolvin (RvT) 4 limits the progression of vascular disease in mouse models of arthritis exacerbated atherosclerotic inflammation.

  • Mary E. Walker
  • , Roberta De Matteis
  •  & Jesmond Dalli

• Article
  14 December 2023 | Open Access

  Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

  Accumulation of lipid-laden macrophages in the arterial wall is a critical step in atherosclerosis. Here, the authors show that downregulation of Zeb1 in macrophages promotes lipid accumulation and atherosclerotic plaque formation while its restoration with macrophage-targeted nanoparticles reverses these effects.

  • M. C. Martinez-Campanario
  • , Marlies Cortés
  •  & Antonio Postigo

• Article
  18 February 2023 | Open Access

  GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

  Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce pathology associated with atherosclerotic disease.

  • Yuanyuan Wei
  • , Beidi Lan
  •  & Yue Wu

• Article
  04 September 2019 | Open Access

  Na⁺-H⁺ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

  Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.

  • Cong-Lin Liu
  • , Xian Zhang
  •  & Guo-Ping Shi

• Article
  25 January 2019 | Open Access

  CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

  In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor LOX-1 through REGγ-mediated degradation of Oct-1.

  • Jiao Fan
  • , Lifeng Liu
  •  & Lingqiang Zhang

• Article | 20 January 2014

  MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

  In the early stages of atherosclerosis, macrophages in the vessel wall convert into foam cells, which promote the rise of atherosclerotic plaques. Here Hamada et al. show that the macrophage transcription factor MafB inhibits foam-cell apoptosis, and that its absence promotes atherosclerosis development in mice.

  • Michito Hamada
  • , Megumi Nakamura
  •  & Satoru Takahashi