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Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor
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Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice
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Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice
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Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
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E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis
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Targeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells
- Yi Jiang
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RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response
- Jinqiu Feng
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A new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma
- Irinka Séraudie
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p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer
- Luiza Steffens Reinhardt
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Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study
- Ali Sepehrinezhad
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Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
- Yi Zhou
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SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation
- Satoshi Kawaguchi
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Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
- Seddik Hammad
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METTL3-dependent m6A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling
- Shuo Wan
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Meeting Report
| Open Access10th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus, 2022
- Panayiota Christodoulou
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HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
- Jialin Li
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Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3β signaling pathway
- Jia Guo
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DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy
- Xiaoyin Ma
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TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs
- Hongbo Wang
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Impact of AMPK on cervical carcinoma progression and metastasis
- Paweł Konieczny
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Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury
- Hongyu Li
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Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome
- Yanyan Liu
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Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury
- Qionghong Xie
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Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice
- Xue Liu
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Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
- Jicong Du
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mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation
- Shuo Wan
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Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss
- Javier Octavio Mejía-Hernández
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Multi-target action of β-alanine protects cerebellar tissue from ischemic damage
- Olga Kopach
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Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin
- Stefan Bornstein
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TRAIL protects the immature lung from hyperoxic injury
- Tayyab Shahzad
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Article
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Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
- Woo Yong Park
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Article
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Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration
- Wei-Shiung Lian
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Article
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Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
- Roman J. Krawetz
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Article
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Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
- Ming Yang
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Article
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B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36
- Hao Zhang
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Article
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MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice
- Sofie Martens
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Article
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Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma
- Soo Ji Jeon
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Article
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RBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling
- Mengyuan Liu
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Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
- J. M. Vicencio
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Article
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Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury
Schematic diagram of the protective effect of MSC-derived exosomes on maintaining SLC7A11 function during ferroptosis involved in CCl4-induced ALI.
- Feiyan Lin
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Article
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Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis
- Josef Stolberg-Stolberg
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Article
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Increased MCL-1 synthesis promotes irradiation-induced nasopharyngeal carcinoma radioresistance via regulation of the ROS/AKT loop
- Ying-Ying Liang
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Article
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Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells
- Muhammad Ali Khan
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Article
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Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16
- Haiyang Zhao
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Article
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PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
- Bo Young Nam
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- & Seung Hyeok Han
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Article
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p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis
- Su Hyun Lee
- , Won Jin Cho
- & Hyeong-Reh C. Kim
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Review Article
| Open Access
The emerging roles of neutrophil extracellular traps in wound healing
- Shuainan Zhu
- , Ying Yu
- & Kefang Guo
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Article
| Open Access
Smooth muscle 22 alpha protein inhibits VSMC foam cell formation by supporting normal LXRα signaling, ameliorating atherosclerosis
- Dan-Dan Zhang
- , Yu Song
- & Mei Han
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Article
| Open Access
The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis
- Runbing Jin
- , Anran Zhao
- & Xiubin Liang
DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease