Erythropoiesis articles within Nature

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• Article
  20 March 2024 | Open Access

  Resilient anatomy and local plasticity of naive and stress haematopoiesis

  This study develops a method for spatially resolving multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice and uncovers heterogeneous haematopoietic stress responses in different bones.

  • Qingqing Wu
  • , Jizhou Zhang
  •  & Daniel Lucas

• Letter | 25 April 2018

  LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

  The HOIL-1 component of the LUBAC ubiquitin ligase complex is required for LUBAC activity, which prevents lethality during embryogenesis by preventing aberrant TNFR1-mediated endothelial cell death and RIPK1-mediated defects in haematopoiesis.

  • Nieves Peltzer
  • , Maurice Darding
  •  & Henning Walczak

• Letter | 06 July 2016

  Resolving early mesoderm diversification through single-cell expression profiling

  Analysis of the transcriptome of more than 1,200 cells from gastrulating mouse embryos using single-cell sequencing, gathering unexpected insights into early mesoderm formation during gastrulation.

  • Antonio Scialdone
  • , Yosuke Tanaka
  •  & Berthold Göttgens

• Letter | 09 June 2013

  ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

  Under stress conditions such as acute blood loss or chronic anaemia, glucocorticoids trigger self-renewal of early burst-forming unit–erythroid (BFU–E) progenitors in the spleen, however, the mechanism of glucocorticoid action is not well understood; here the RNA binding protein ZFP36L2 is identified as a transcriptional target of the glucocorticoid receptor in BFU-Es and is shown to be involved in the process of erythroid cell expansion following exposure to glucocorticoids.

  • Lingbo Zhang
  • , Lina Prak
  •  & Harvey F. Lodish

• Letter | 30 September 2012

  Clonal allelic predetermination of immunoglobulin-κ rearrangement

  Immunoglobulin genes are expressed from either the maternal or paternal chromosome; it is now shown that in early haematopoietic stem cells, an individual cell can choose either of the two alleles, but as they develop they become committed to only one.

  • Marganit Farago
  • , Chaggai Rosenbluh
  •  & Yehudit Bergman

• Article | 12 August 2010

  Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

  The identity of the cells that form the haematopoietic stem cell (HSC) niche in bone marrow has been unclear. These authors identify nestin-expressing mesenchymal stem cells as niche-forming cells. These nestin-expressing cells show a close physical association with HSCs and express high levels of genes involved in HSC maintenance, and their depletion reduces bone marrow homing of haematopoietic progenitors.

  • Simón Méndez-Ferrer
  • , Tatyana V. Michurina
  •  & Paul S. Frenette

• Letter | 14 February 2010

  Blood stem cells emerge from aortic endothelium by a novel type of cell transition

  One of two papers showing the generation of haematopoietic stem cells (HSCs) from the ventral wall of the dorsal aorta in live zebrafish embryos. Here, using imaging of live zebrafish, HSCs are shown to emerge directly from the aorta floor. This process does not involve cell division but movement of single endothelial cells out of the aorta ventral wall into the sub aortic space, where they transform into haematopoietic cells.

  • Karima Kissa
  •  & Philippe Herbomel