Enteric neuropathies articles within Nature Communications

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• Article
  20 March 2024 | Open Access

  Autologous cell transplantation for treatment of colorectal aganglionosis in mice

  Neurointestinal diseases cause significant morbidity and effective treatments are lacking. Here, authors perform autologous cell transplantation of enteric neural stem cells in a mouse model of colonic aganglionosis and report restoration of colonic contractile activity.

  • Weikang Pan
  • , Ahmed A. Rahman
  •  & Ryo Hotta

• Article
  15 April 2023 | Open Access

  Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

  Hirschsprung disease is caused by defects in enteric neural crest cell. Here, using induced pluripotent stem cell-based models of Hirschsprung and single-cell transcriptomic analysis the authors define various factors associated with Hirschsprung pathogenesis.

  • Zhixin Li
  • , Kathy Nga-Chu Lui
  •  & Elly Sau-Wai Ngan