Endoderm articles within Nature Communications

Featured

• Article
  18 January 2024 | Open Access

  Sox9 regulates alternative splicing and pancreatic beta cell function

  Sox9 is a well-known transcriptional regulator of embryonic pancreas and endocrine cell development. Here, the authors show that loss of Sox9 in mature beta cells disrupts alternative splicing patterns and impairs insulin secretion, with significant implications for cellular function.

  • Sapna Puri
  • , Hasna Maachi
  •  & Matthias Hebrok

• Article
  30 September 2023 | Open Access

  IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

  Omrani, Krepelova et al. report that aging-induced proinflammatory IFNγ/Stat1 signalling primes intestinal stem cells to a secretory fate and to antigen presenting cells impairing the regenerative capacity of the aging gut epithelium.

  • Omid Omrani
  • , Anna Krepelova
  •  & Francesco Neri

• Article
  26 May 2022 | Open Access

  Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions

  The primitive gut tube gives rise to all major internal organs, while underlying regulatory mechanisms are unclear. Here, the authors analyze its chromatin landscape at the single-cell level and define the epigenetic regulation of lineage fate decisions and plasticity in organ development and homeostasis.

  • Ryan J. Smith
  • , Hongpan Zhang
  •  & Tae-Hee Kim

• Article | 16 March 2015

  HEB associates with PRC2 and SMAD2/3 to regulate developmental fates

  In embryonic stem cells, extracellular signals are required to derepress developmental promoters to drive lineage specification, but the proteins involved in this process remain unknown. Here the authors show that the protein HEB directly associates with the Polycomb repressive complex 2 at genes involved in mesoderm and endoderm specification.

  • Se-Jin Yoon
  • , Joseph W. Foley
  •  & Julie C. Baker