Endocytosis articles within Nature

Featured

  • Article |

    A mechanism involving intracellular recycling of the morphogen Decapentaplegic (Dpp) underlies the scaling of the Dpp gradient in the Drosophila wing disc, and this is modulated by the extracellular factors Pentagone and Dally.

    • Maria Romanova-Michaelides
    • , Zena Hadjivasiliou
    •  & Marcos Gonzalez-Gaitan

  • Letter |

    Super-resolution imaging provides direct evidence in live cells that membrane fusion and fission are mediated through an intermediate hemi-fused structure, where fusion and calcium/dynamin-dependent fission mechanisms compete to determine the transition of the intermediate to fusion or fission.

    • Wei-Dong Zhao
    • , Edaeni Hamid
    •  & Ling-Gang Wu

  • Letter |

    Central spindle asymmetry, generated by the kinesin Klp10A and its antagonist Patronin, polarizes endosome motility and provides a mechanism for the asymmetric segregation of signalling endosomes observed in a variety of asymmetrically dividing cell types.

    • Emmanuel Derivery
    • , Carole Seum
    •  & Marcos Gonzalez-Gaitan

  • Letter |

    The GTPase dynamin provides the driving force for fission of membrane-bound vesicular structures; here, it is shown that dynamin-driven membrane fission proceeds in two mechanistically distinct stages that are separated by a metastable hemi-fission intermediate that requires GTP hydrolysis for progression to full fission.

    • Juha-Pekka Mattila
    • , Anna V. Shnyrova
    •  & Vadim A. Frolov

  • Article |

    This study describes a fast, clathrin-independent endocytic pathway mediated by endophilin, dynamin and actin; the pathway is activated by ligand binding to a variety of cargo receptors, and endophilin-mediated endocytosis occurs primarily at the leading edges of cells where lamellipodin and the lipid PtdIns(3,4)P2 ensure endophilin targeting.

    • Emmanuel Boucrot
    • , Antonio P. A. Ferreira
    •  & Harvey T. McMahon

  • Article |

    Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles; however, when ultrafast endocytosis does not occur (for example, in experiments at room temperature rather than physiological temperature), clathrin-mediated endocytosis does happen at the plasma membrane.

    • Shigeki Watanabe
    • , Thorsten Trimbuch
    •  & Erik M. Jorgensen

  • Article |

    Sustained neurotransmission requires recycling of synaptic vesicles, but the proposed mechanisms have been controversial; here a ‘flash-and-freeze’ method for electron microscopy reveals a new ultrafast form of endocytosis that is actin- and dynamin-dependent and occurs within 100 milliseconds of stimulation.

    • Shigeki Watanabe
    • , Benjamin R. Rost
    •  & Erik M. Jorgensen

  • Letter |

    Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.

    • York Posor
    • , Marielle Eichhorn-Gruenig
    •  & Volker Haucke

  • Letter |

    In vivo and in vitro studies show that the stem-cell E3 ubiquitin ligases RNF43 and ZNRF3 act as tumour suppressors in colorectal cancer models, and are involved in the negative regulation of the cancer-associated Wnt signalling pathway through limiting the cell-surface expression of Wnt receptors.

    • Bon-Kyoung Koo
    • , Maureen Spit
    •  & Hans Clevers

  • News & Views |

    Cargo-carrying vesicles can assemble from hundreds of locations on the cell membrane, but how these sites are selected has been unclear. A small family of membrane-sculpting proteins may select the perfect location.

    • Linton M. Traub
    •  & Beverly Wendland

  • Article |

    A new strategy is presented to accurately profile the activity of human genes in endocytosis by combining genome-wide RNAi, automated high-resolution confocal microscopy and quantitative multi-parametric image analysis. Several novel components of endocytosis and endosome trafficking were uncovered; a systems analysis further revealed that the cell regulates the number, size and concentration of cargo within endosomes.

    • Claudio Collinet
    • , Martin Stöter
    •  & Marino Zerial

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