Endocrine cancer

Endocrine cancers are a mixed group of diseases characterized by uncontrolled cellular proliferation of the hormone-producing glands of the endocrine system. These include the thyroid, adrenal, pancreas, parathyroid and pituitary glands.

Latest Research and Reviews

News and Comment

  • News & Views |

    Neuroendocrine neoplasms are derived from the diffuse endocrine system and represent a spectrum of tumours with a diverse range of molecular abnormalities, functionality and anatomical locations. Here, some key advances in molecular diagnosis, functional imaging and therapeutic strategies that have been published in 2020 are discussed.

    • Martyn E. Caplin
    •  & Gowri M. Ratnayake
  • News & Views |

    In two phase III trials, surufatinib, a novel oral tyrosine kinase inhibitor targeting immune cells and angiogenesis, was effective for treating pancreatic and extra-pancreatic neuroendocrine tumours. These findings further expand the therapeutic options for patients with gastro–entero–pancreatic, thymic and lung neuroendocrine tumours.

    • Anna Koumarianou
    •  & Gregory Kaltsas
  • Comments & Opinion |

    The first International Symposium on Phaeochromocytoma in 2005 was followed by considerable progress in the field, largely owing to the many collaborations and networks stimulated by that and subsequent meetings. The rich hereditary background of phaeochromocytomas has since provided for strong interdisciplinary links of genetics with personalized diagnostics, imaging and therapeutic interventions.

    • Karel Pacak
    • , Graeme Eisenhofer
    •  & Arthur S. Tischler
  • Comments & Opinion |

    This Comment article provides a behind-the-scenes perspective and update of our 2016 Review, which discussed possible factors contributing to thyroid cancer incidence trends worldwide. We also highlight promising research directions that are improving the understanding of thyroid cancer aetiology.

    • Cari M. Kitahara
    •  & Julie A. Sosa
  • News & Views |

    Neuroendocrine liver metastases often require multiple modes of treatment to attain disease control, which can utilize various forms of radiolabelled agents either delivered systemically or preferentially towards the liver. A recent trial suggested both safety and efficacy of a novel approach of combining the two to provide a radiation ‘boost’ to hepatic deposits.

    • Andrea Frilling
    •  & Ashley Kieran Clift
  • Comments & Opinion |

    Studies uncovering the cellular mechanisms of adaptation to varying oxygen levels were recognized with the 2019 Nobel Prize in Physiology or Medicine. Here, we focus on the remarkable parallels between the pathways regulating oxygen availability and those driving rare neuroendocrine tumours, phaeochromocytomas and paragangliomas, and discuss the translational implications of this connection.

    • Patricia L. M. Dahia
    •  & Rodrigo A. Toledo