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| Open AccessTissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation
Ommatidial rotation in the Drosophila eye is a regulated process and a Planar Cell Polarity (PCP) cell motility model. Here, the authors show that tissue fluidity via junctional remodeling, as regulated by the PCP effector kinase Nemo, is critical for this cell motility process.
- Nabila Founounou
- , Reza Farhadifar
- & Marek Mlodzik
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Article
| Open AccessActuation enhances patterning in human neural tube organoids
Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstrating that mechanical forces increase growth and enhance patterning.
- Abdel Rahman Abdel Fattah
- , Brian Daza
- & Adrian Ranga
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Article
| Open AccessFoxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo
Vertebrate telencephalon formation requires Foxg-Fgf8 cross-regulation, but while ascidians express Foxg in the neural plate, they lack a telencephalon. Here the authors show that Foxg loss does not affect ascidian brain formation, indicating that telencephalon evolution required recruitment of Fgf downstream of Foxg.
- Boqi Liu
- & Yutaka Satou
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Article
| Open AccessSelf-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential activation of localised Fgf then Wnt signalling.
- Nozomu Takata
- , Eriko Sakakura
- & Yoshiki Sasai
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Article
| Open AccessDiverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
Asymmetric feather vane shape was a critical innovation in feather evolution and adaptation for flight. Here, Li and colleagues characterize the multi-module regulatory network that controls feather vane shape and underlies feather diversification.
- Ang Li
- , Seth Figueroa
- & Cheng-Ming Chuong
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Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells
The histone demethylase Lsd1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Here, the authors show that the loss of Lsd1 in the trophectoderm of mouse embryos leads to premature differentiation of trophoblast stem cells, partially due to de-repression of the transcription factor Ovol2.
- Dongmei Zhu
- , Stefanie Hölz
- & Roland Schüle