DNA (deoxyribonucleic acid) is the nucleic acid polymer that forms the genetic code for a cell or virus. Most DNA molecules consist of two polymers (double-stranded) of four nucleotides that each consist of a nucleobase, the carbohydrate deoxyribose and a phosphate group, where the carbohydrate and phosphate make up the backbone of the polymer.

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News and Comment

  • News and Views |

    The biological function and origin of m6A in DNA have been widely debated. A new study demonstrates that the majority of m6A in DNA originates from RNA catabolism via a nucleotide salvage pathway.

    • Paolo Spingardi
    •  & Skirmantas Kriaucionis
  • News and Views |

    Using new letters of DNA to encode information promises to expand the genetic code in a transformative way. A new semisynthetic organism has been created that uses 67 codons for protein biosynthesis, with three new codons based on unnatural nucleotides.

    • Michael C. Jewett
    •  & Michael J. Hammerling
  • News and Views |

    Although many metabolic dependencies of cancer cells are well documented, altered cancer metabolism has not always been considered an active driver of tumorigenesis. Restrictive glutamine availability is now shown to promote colorectal cancer by lowering α-ketoglutarate levels and thereby promoting DNA hypermethylation, Wnt signaling and cellular de-differentiation.

    • Dana Krauß
    •  & Eyal Gottlieb
    Nature Cancer 1, 267-269