DNA probes

DNA probes are stretches of single-stranded DNA used to detect the presence of complementary nucleic acid sequences (target sequences) by hybridization. DNA probes are usually labelled, for example with radioisotopes, epitopes, biotin or fluorophores to enable their detection.

Latest Research and Reviews

Research
01 April 2022 | Open Access

Improved calibration of electrochemical aptamer-based sensors
- Alex M. Downs
- , Julian Gerson
- & Kevin W. Plaxco
Scientific Reports 12, 5535
Research
07 October 2021 | Open Access

Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins
- Cassandra M. Stawicki
- , Torri E. Rinker
- & Parag Mallick
Scientific Reports 11, 19921
Protocols | 28 July 2021

Regional and functional division of functional elements of solid-state nanochannels for enhanced sensitivity and specificity of biosensing in complex matrices

This protocol enables explicit regional and functional division of functional elements of solid-state nanochannels to improve the sensitivity and specificity of bioanalysis in complex matrices.
- Pengcheng Gao
- , Dagui Wang
- & Fan Xia
Nature Protocols 16, 4201-4226
Research
02 June 2021 | Open Access

Confirming putative variants at ≤ 5% allele frequency using allele enrichment and Sanger sequencing
- Yan Helen Yan
- , Sherry X. Chen
- & David Yu Zhang
Scientific Reports 11, 11640
Research | 18 September 2020

Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription

A one-pot enzymatic assay for the fluorescence detection of RNA accurately and rapidly detects specific viral and bacterial pathogens, as shown for SARS-CoV-2 RNA in clinical samples.
- Chang Ha Woo
- , Sungho Jang
- & Jeong Wook Lee
Nature Biomedical Engineering 4, 1168-1179
Research
23 March 2020 | Open Access

Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids

Size-selective discrimination is an issue in biosensing. Here, the authors report on a size selective DNA nanocage which excludes agents based on size and protects the probes against degradation, and demonstrate the discrimination between mature and precursor miRNA.
- Xiaoyi Fu
- , Guoliang Ke
- & Weihong Tan
Nature Communications 11, 1518

All Research & Reviews

News and Comment

News & Views | 19 August 2022

Sensitive detection of SARS-CoV-2 on paper

An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants, with single-nucleotide specificity.
- Kaiyue Wu
- & Alexander A. Green
Nature Biomedical Engineering 6, 928-929
Research Highlights | 04 February 2021

DNA-PAINT takes a left turn

DNA-PAINT with left-handed DNA oligomers enables imaging of nuclear structures with reduced background.
- Rita Strack
Nature Methods 18, 122
Research Highlights | 20 December 2018

Detecting protein glycosylation
- Lei Tang
Nature Methods 16, 26
Research Highlights | 17 May 2018

I spy in my nuclei

This study identifies a human antibody fragment that recognizes i-motifs and shows that these DNA structures are present in the nuclei of human cells.
- Katharine H Wrighton
Nature Reviews Chemistry 2, 48
Research Highlights | 30 January 2018

Off-the-shelf super-resolution microscopy in whole cells

The combination of DNA-PAINT and spinning-disk confocal microscopy makes super-resolution microscopy in whole cells affordable and easy to implement.
- Christian Schnell
Nature Methods 15, 96
Research Highlights | 31 March 2015

Peering inside protein complexes with AFM

Atomic force microscopy is applied to image the location of chemical groups inside single protein complexes.
- Allison Doerr
Nature Methods 12, 284

All News & Comment

DNA probes

Latest Research and Reviews

Improved calibration of electrochemical aptamer-based sensors

Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins

Regional and functional division of functional elements of solid-state nanochannels for enhanced sensitivity and specificity of biosensing in complex matrices

Confirming putative variants at ≤ 5% allele frequency using allele enrichment and Sanger sequencing

Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription

Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids

News and Comment

Sensitive detection of SARS-CoV-2 on paper

DNA-PAINT takes a left turn

Detecting protein glycosylation

I spy in my nuclei

Off-the-shelf super-resolution microscopy in whole cells

Peering inside protein complexes with AFM

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