DNA mismatch repair articles within Nature Communications

Featured

• Article
  27 March 2024 | Open Access

  Real-time monitoring of replication errors’ fate reveals the origin and dynamics of spontaneous mutations

  An interdisciplinary approach following replication errors in Escherichia coli unveils that many spontaneous mutations originate from inefficient repair, and that repair capacity is variable between single cells within a bacterial population.

  • Chiara Enrico Bena
  • , Jean Ollion
  •  & Marina Elez

• Article
  03 October 2022 | Open Access

  MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair

  MutS and MutL homologs are thought to form a stable complex to execute mismatch repair. This work shows that E. coli MutS only acts as a mismatch-dependent clamp-loader that assembles the MutL sliding clamp.

  • Xiao-Wen Yang
  • , Xiao-Peng Han
  •  & Jiaquan Liu

• Article
  17 May 2022 | Open Access

  Mutational landscape of normal epithelial cells in Lynch Syndrome patients

  It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS patients are genomically stable, while ancestor cells of neoplastic tissues undergo multiple cycles of clonal evolution.

  • Bernard C. H. Lee
  • , Philip S. Robinson
  •  & Michael R. Stratton

• Article
  09 February 2022 | Open Access

  Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

  Prime Editing is a versatile genome engineering tool. Here, the authors identify the DNA repair pathway known as mismatch repair as inhibitory for Prime Editing, thus, loss of mismatch repair enhances the efficiency of Prime Editing.

  • J. Ferreira da Silva
  • , G. P. Oliveira
  •  & J. I. Loizou

• Article
  18 August 2021 | Open Access

  Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging

  Proper meiotic chromosome segregation requires mismatch repair genes MLH1 and MLH3, of which variants occur in the human population. Here, the authors use computational predictions and yeast assays to select human MLH1/3 variants for modelling in mice, observing reproductive defects from abnormal levels of crossing over.

  • Priti Singh
  • , Robert Fragoza
  •  & John C. Schimenti

• Article
  22 November 2019 | Open Access

  MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair

  The mechanics of MMR strand specific excision that begins at a distant ssDNA break are not yet clear. Here the authors have used multiple single molecule imaging techniques to visualize the behavior of MMR components on mismatched DNA substrates and reveal an exonuclease-independent mechanism for E.coli MMR.

  • Jiaquan Liu
  • , Ryanggeun Lee
  •  & Richard Fishel

• Article
  02 September 2019 | Open Access

  Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

  Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.

  • Yusuke Matsuno
  • , Yuko Atsumi
  •  & Ken-ichi Yoshioka

• Article
  29 August 2019 | Open Access

  A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

  During meiotic recombination, genetic information is transferred or exchanged between parental chromosome copies. Using a large hybrid mouse pedigree, the authors generated high-resolution maps of these transfer/exchange events and discovered new properties governing their processing and resolution.

  • Ran Li
  • , Emmanuelle Bitoun
  •  & Simon R. Myers

• Article
  27 January 2017 | Open Access

  A non-canonical mismatch repair pathway in prokaryotes

  Despite the importance of mismatch repair for genome stability, many Archaea and almost all Actinobacteria lack MutS and MutL proteins. Here the authors, usingMycobacterium smegmatisas a model, report that NucS/EndoMS endonuclease acts in a distinct mismatch repair pathway.

  • A. Castañeda-García
  • , A. I. Prieto
  •  & J. Blázquez

• Article
  24 October 2013 | Open Access

  Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

  The chemotherapeutic drug 5-fluorouracil causes cell toxicity by inducing DNA lesions. Here, SenGupta et al. use C. elegansto show that components of the base excision repair and the mismatch repair pathways function together in the response to 5-fluorouracil, resulting in activation of the DNA damage checkpoint and induction of autophagy.

  • Tanima SenGupta
  • , Maria Lyngaas Torgersen
  •  & Hilde Nilsen