DNA computing articles within Nature Communications

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  • Article
    | Open Access

    Various methods, using DNA, have been reported for the recording of biomolecular interactions, but most are either destructive in nature or are limited to reporting pairwise interactions. Here the authors develop DNA-based motors, termed ‘crawlers’, that roam around and record their trajectories to allow the examination of molecular environments.

    • Sungwook Woo
    • , Sinem K. Saka
    •  & Peng Yin

  • Comment
    | Open Access

    The commercialization of DNA tagging is a growing trend that demonstrates the increasing practicality of this novel approach. This interdisciplinary technology is based on the distinctive characteristics of DNA as a molecule that can remain stable in varying environmental conditions and store data following appropriate preparation. Moreover, newly developed technologies could simplify DNA synthesis and the encoding of data within DNA. The implementation of DNA tagging presents distinctive benefits in comparison to conventional labelling techniques, including universal product code (UPC) barcoding, radio-frequency identification (RFID), quick response (QR) codes, and Bluetooth technologies, by surmounting the limitations encountered by these systems. The discourse pertains to extant DNA-tagging mechanisms along with prospective implementations in a wide range of domains, including but not limited to art, the metaverse, forensics, wildlife monitoring, and the military. The potential of DNA labelling in various contexts underscores the importance of continued research and development in this rapidly evolving field.

    • Adam Kuzdraliński
    • , Marek Miśkiewicz
    •  & Bogdan Księżopolski

  • Article
    | Open Access

    Conformational cooperativity is a universal molecular effect mechanism and plays a critical role in signalling pathways. Here the authors present a programmable conformational cooperativity strategy to construct the oligo-protein signal transduction platform for logic operations and gene regulations which can be cooperatively regulated by conformational signals.

    • Yuan Liang
    • , Yunkai Qie
    •  & Cheng Zhang

  • Article
    | Open Access

    Synthetic DNA constructs can to used to recognise and respond to input signals. Here the authors present complex DNA nanostructures with toehold-free strand displacement for generation of ON/OFF switches and Boolean gates.

    • Hong Kang
    • , Tong Lin
    •  & Bryan Wei

  • Article
    | Open Access

    Gaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliable crystal growth in a simple manner.

    • Samuel W. Schaffter
    • , Dominic Scalise
    •  & Rebecca Schulman

  • Article
    | Open Access

    DNA strand displacement reactions can be difficult to scale up for computational tasks. Here the authors develop DNA switching circuits that achieve high-speed computing with fewer molecules.

    • Fei Wang
    • , Hui Lv
    •  & Chunhai Fan

  • Article
    | Open Access

    Biomolecular cyptography that exploits specific interactions could be used for data encryption. Here the authors use the folding of M13 DNA to encrypt information for secure communication.

    • Yinan Zhang
    • , Fei Wang
    •  & Chunhai Fan

  • Article
    | Open Access

    DNA based technology holds promise for non-volatile memory and computational tasks, yet the relatively slow hybridization kinetics remain a bottleneck. Here, Song et al. have developed an electric field-induced hybridization platform that can speed up multi-bit memory and logic operations.

    • Youngjun Song
    • , Sejung Kim
    •  & Xiaohua Huang

  • Article
    | Open Access

    DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagereet al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler.

    • Anupama J. Thubagere
    • , Chris Thachuk
    •  & Lulu Qian

  • Article
    | Open Access

    Existing DNA based circuits, designed to perform logic operations and signal processing, are generally responsive to DNA or RNA inputs. Here, the authors show that antibodies can actuate DNA logic gates, opening the way to applications of DNA computing in diagnostics and biomedicine.

    • Wouter Engelen
    • , Lenny H. H. Meijer
    •  & Maarten Merkx

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