DNA adducts articles within Nature

Featured

• Article | 27 April 2022

  Breakage of cytoplasmic chromosomes by pathological DNA base excision repair

  DNA damage during chromothripsis is caused by deoxyinosine formation on accumulated RNA–DNA hybrids in micronuclei that are then recognized by N-methyl-purine DNA glycosylase and cleaved by apurinic/apyrimidinic endonuclease.

  • Shangming Tang
  • , Ema Stokasimov
  •  & David Pellman

• Article | 24 June 2020

  Pervasive lesion segregation shapes cancer genome evolution

  Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and consequent tumour heterogeneity.

  • Sarah J. Aitken
  • , Craig J. Anderson
  •  & Martin S. Taylor

• Article | 04 March 2020

  Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

  DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.

  • Michael R. Hodskinson
  • , Alice Bolner
  •  & Puck Knipscheer