Disease model articles within Nature

Featured

  • Article |

    Experiments using conserved tumour models show that the G-protein-coupled receptor TkR99D in Drosophila Malphigian tubular stellate cells and NK3R in mouse renal tubules link malignant tumours to defective excretory functions.

    • Wenhao Xu
    • , Gerui Li
    •  & Wei Song

  • Article |

    A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.

    • Yoshihiro Yamanaka
    • , Sofiane Hamidi
    •  & Cantas Alev

  • Article |

    Lymphatic endothelium secretes factors needed for heart growth and repair such as RELN, which helps with heart regeneration and cardioprotection after myocardial infarction.

    • Xiaolei Liu
    • , Ester De la Cruz
    •  & Guillermo Oliver

  • Letter |

    Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.

    • Eliezer Calo
    • , Bo Gu
    •  & Joanna Wysocka

  • Letter |

    Genomic duplications in the SOX9 region are associated with human disease phenotypes; a study using human cells and mouse models reveals that the duplications can cause the formation of new higher-order chromatin structures called topologically associated domains (TADs) thereby resulting in changes in gene expression.

    • Martin Franke
    • , Daniel M. Ibrahim
    •  & Stefan Mundlos

  • Article |

    This study identifies a deubiquitinase (DUB) that specifically recognises and cleaves linear ubiquitin chains, implicating linear (de)ubiquitination in Wnt signalling and angiogenesis; mutations in gumby cause defects in angiogenesis in mice, and structural and biochemical analysis shows that gumby encodes a linear-ubiquitin-specific DUB.

    • Elena Rivkin
    • , Stephanie M. Almeida
    •  & Sabine P. Cordes

  • Outlook |

    Despite its rarity, multiple myeloma is an ideal testing ground for cancer biology, says William Matsui.

    • William Matsui

  • Outlook |

    Finding a treatment for the bone destruction caused by myeloma helped researchers understand the biology of bone.

    • Jennifer Berglund

  • News |

    Heart disorder joins growing list of conditions getting the 'disease in a dish' treatment.

    • Ewen Callaway

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