Cytological techniques

Cytological techniques are methods used in the study or manipulation of cells. These include methods used in cell biology to culture, track, phenotype, sort and screen cells in populations or tissues, and molecular methods to understand cellular function.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Four new studies in Nature report multi-tissue analyses of somatic mutations from human donors, with insights into cell lineage commitment during embryonic development, as well as tissue-specific aspects of mutagenesis.

    • Darren J. Burgess
  • Comments & Opinion |

    High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computational data analysis to avoid artefacts and misinterpretation of results. Here we discuss pitfalls frequently encountered during high-dimensional cytometry data analysis and aim to provide a basic framework and recommendations for reporting and analyzing these datasets.

    • Thomas Liechti
    • , Lukas M. Weber
    •  & Florian Mair
    Nature Immunology 22, 1190-1197
  • Research Highlights |

    A yeast cell culture approach mimics the benefits of somatic hypermutation to accelerate the discovery of desirable antibodies.

    • Katarzyna Marcinkiewicz
    Nature Methods 18, 860
  • Research Highlights |

    Two new studies in Science use lineage tracking in humans to show that among the first few embryonic cells originating from post-fertilization cell divisions, there can be substantial imbalance in their contributions to mature tissues.

    • Darren J. Burgess
  • Research Highlights |

    Human tonsil organoids recapitulate key features of the antigen-specific B cell response.

    • Madhura Mukhopadhyay
    Nature Methods 18, 229