Featured
-
-
Letter |
Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
A new model of cardiac trabeculation in mice is presented in which NOTCH1 and NRG1 have opposing roles in extracellular matrix degradation and synthesis that are essential for defining trabecular architecture.
- Gonzalo del Monte-Nieto
- , Mirana Ramialison
- & Richard P. Harvey
-
Letter |
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality
The O-glycosylation enzyme Galnt11 has an important role in heterotaxy, a disorder of left–right body patterning or laterality: Galnt11 modulates Notch signalling which alters cilia types at the embryonic left–right organizer, therefore determining laterality.
- Marko T. Boskovski
- , Shiaulou Yuan
- & Mustafa K. Khokha
-
Research Highlights |
Clues from big-hearted mice
-
Letter |
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
The generation of induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders promises to help the basic understanding of complex diseases and the development of therapeutics. Here iPSCs have been generated from patients with LEOPARD syndrome, a developmental disorder with pleiomorphic effects on several tissues and organs. The iPSCs are characterized and the phenotype of cardiomyocytes derived from these cells is investigated.
- Xonia Carvajal-Vergara
- , Ana Sevilla
- & Ihor R. Lemischka