Featured
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Letter |
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1
Complement components activate and recruit immune cells, promoting host defense and inflammatory disease. Jörg Köhl and his colleagues demonstrate that IgG1 immune complexes inhibit C5a-mediated inflammatory responses and disease. The inhibitory effect of IgG1 immune complexes requires galactosylation of the antibody, binding to the inhibitory IgG receptor FcγRIIB and the association of FcγRIIB with the C-type lectin–like receptor dectin-1.
- Christian M Karsten
- , Manoj K Pandey
- & Jörg Köhl
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Correspondence |
Mannose-binding lectin—the forgotten molecule?
- Michael Osthoff
- , George Trendelenburg
- & Marten Trendelenburg
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Correspondence |
Reply to: Mannose-binding lectin—the forgotten molecule?
- Costantino Iadecola
- & Josef Anrather
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Letter |
Identification of a central role for complement in osteoarthritis
Osteoarthritis, the breakdown of cartilage in synovial joints, has long been viewed as the result of 'wear and tear', but this report shows that dysregulation of the complement system has an active role in the pathogenesis of this disease.
- Qian Wang
- , Andrew L Rozelle
- & William H Robinson
ApoE attenuates unresolvable inflammation by complex formation with activated C1q