Circadian rhythms articles within Nature Communications

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  • Article
    | Open Access

    The circadian rhythms of peripheral clocks are difficult to study. Here the authors demonstrate a technique to image clock gene expression simultaneously in various tissues of freely moving mice, and use it to show that a long duration light pulse resets the rhythms in the olfactory bulb faster than other tissues.

    • Toshiyuki Hamada
    • , Kenneth Sutherland
    •  & Ken-ichi Honma

  • Article
    | Open Access

    Circadian rhythms synchronize important biological processes, and are thought to primarily be entrained by environmental cycles in light and temperature, with little or no role for social interactions. Here, Fuchikawa et al. show that social cues among honeybees can entrain these rhythms even in the presence of conflicting light-dark cycles.

    • Taro Fuchikawa
    • , Ada Eban-Rothschild
    •  & Guy Bloch

  • Article
    | Open Access

    Circadian rhythms are central to health and disease and there is renewed interest in chronotherapy. Here, the authors present a mouse with an artificial circadian clock that can be pharmacologically tuned, providing a tool for future studies of circadian biology and therapy.

    • Matthew D’Alessandro
    • , Stephen Beesley
    •  & Choogon Lee

  • Article
    | Open Access

    Bile acids are important for the absorption of nutrients. Here the authors provide a molecular explanation for the oscillatory release of bile acids, showing that diurnal expression of the transcription factor KLF15 regulates FGF15 secretion from enterocytes, which then inhibits bile acid synthesis in the liver.

    • Shuxin Han
    • , Rongli Zhang
    •  & Mukesh K. Jain

  • Article |

    The mammalian circadian clock is influenced by nuclear receptors such as Rev-Erb. Here Kumar et al. show that ecdysone-induced protein 75 (E75), a fly homologue of Rev-Erb, regulates circadian rhythms in Drosophila, and demonstrate that E75 protects the clock against environmental stressors.

    • Shailesh Kumar
    • , Dechun Chen
    •  & Amita Sehgal

  • Article |

    The CWO protein is part of a feedback loop that contributes to the high-amplitude circadian oscillation in Drosophila. Here, the authors identify microRNA let-7 as a regulator of circadian rhythm via repression of cwo, and show the circadian expression of let-7 is regulated by ecdysteroid and its receptor.

    • Wenfeng Chen
    • , Zhenxing Liu
    •  & Zhangwu Zhao

  • Article |

    Whether circadian rhythms occur in settings where clock gene expression is suppressed, such as systemic inflammation, is unclear. Here, the authors examine gene expression and metabolites in the lungs of endotoxemic mice and show that inflammation causes changes in circadian rhythms at the cellular and molecular level.

    • Jeffrey A. Haspel
    • , Sukrutha Chettimada
    •  & Augustine M.K. Choi

  • Article |

    Body clocks modulate physiological processes to follow a day–night cycle, but whether animals exposed to constant darkness express circadian rhythms is unknown. Here the authors examine the expression of circadian genes in Mexican cavefish, and find that these resemble a pattern expected from exposure to constant daylight.

    • Andrew Beale
    • , Christophe Guibal
    •  & David Whitmore

  • Article
    | Open Access

    Monarch Butterflies (Danaus plexippus) use their antennae for orientation during their autumnal migration. Guerra and colleagues differentially disrupt clock gene expression in each antenna and find that the individual outputs are integrated and processed to allow precise control of orientation behaviour.

    • Patrick A. Guerra
    • , Christine Merlin
    •  & Steven M. Reppert

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