Ciliogenesis articles within Nature

Featured

• Article | 04 June 2014

  miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

  Loss-of-function studies of the miR-34/449 microRNA family in mouse and Xenopus reveal their evolutionarily conserved role in ciliogenesis by repressing expression of the centriolar protein Cp110.

  • Rui Song
  • , Peter Walentek
  •  & Lin He

• Letter | 13 November 2013

  The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

  The O-glycosylation enzyme Galnt11 has an important role in heterotaxy, a disorder of left–right body patterning or laterality: Galnt11 modulates Notch signalling which alters cilia types at the embryonic left–right organizer, therefore determining laterality.

  • Marko T. Boskovski
  • , Shiaulou Yuan
  •  & Mustafa K. Khokha

• Letter | 15 April 2010

  Functional genomic screen for modulators of ciliogenesis and cilium length

  Primary cilia are tiny hair-like structures expressed on the surface of eukaryotic cells. They participate in a range of processes, such as sensing the extracellular environment and regulating signalling pathways during development. Here, a functional genomic screen is presented that used RNA interference to identify human genes involved in controlling ciliogenesis. Several positive and negative ciliogenesis modulators with broad-ranging functions were found.

  • Joon Kim
  • , Ji Eun Lee
  •  & Joseph G. Gleeson