Chromosome segregation

Chromosome segregation occurs in mitosis and is the process by which the mitotic spindle separates the duplicated chromosomes into daughter cells.

Latest Research and Reviews

News and Comment

  • News & Views |

    A genome-wide CRISPR screen finds CIP2A as a new synthetic lethal target for BRCA1- and BRCA2-deficient cells. Unlike PARP inhibition that increases replication-induced DNA double-strand breaks and radial chromosomes, depleting CIP2A or disrupting its interaction with TOPBP1 increases micronuclei and chromosomal missegregation, revealing a mitotic target for BRCA-mutated tumors.

    • Demis Menolfi
    •  & Shan Zha
    Nature Cancer 2, 1296-1297
  • News & Views |

    Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

    • Ali Motazedian
    •  & Mark A. Dawson
    Nature Cell Biology 23, 295-296
  • Comments & Opinion
    | Open Access

    Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

    • Miryam Müller
    • , Stephanie May
    •  & Thomas G. Bird
  • News & Views |

    After mitosis chromosomes are drastically reshaped. A study now charts the dynamics of this conformational change at high temporal resolution. During the shift from one loop-forming complex (condensin) to another (cohesin), an intermediate chromosome folding state exists in which neither of these complexes are associated with chromatin.

    • Ning Qing Liu
    •  & Elzo de Wit
    Nature Cell Biology 21, 1303-1304