Chromosome condensation articles within Nature Communications

Featured

• Article
  17 August 2020 | Open Access

  Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

  Epigenetic information is transmitted from mother to daughter cells through mitosis. Here, the authors isolate native chromosomes from metaphase-arrested cells and perform LC-MS/MS to identify chromosome-bound proteins in pluripotent stem cells during mitosis and reveal that PRC2, DNA methylation and Mecp2 are required to maintain chromosome compaction.

  • Dounia Djeghloul
  • , Bhavik Patel
  •  & Amanda G. Fisher

• Article
  30 July 2020 | Open Access

  Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP

  Protein, MatP, binds to and delays segregation of the ter region of the bacterial chromosome before cell division. Here, the authors show that MatP displays multiple activities to promote optimal pairing of sister ter regions until cell division.

  • Estelle Crozat
  • , Catherine Tardin
  •  & François Cornet

• Article
  23 July 2015 | Open Access

  Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation

  Chromosome condensation is a prerequisite for faithful segregation of chromosomes to daughter cells. Here, the authors show that the condensin complex binds to protein-coding genes in a transcription-dependent manner during condensation, and reduces unwound DNA segments generated by transcription.

  • Takashi Sutani
  • , Toyonori Sakata
  •  & Katsuhiko Shirahige