Cells | Nature Reviews Cardiology

Research Highlight | 15 June 2021

Targeting the adipose tissue to protect the heart

Treatment with atglistatin, an inhibitor of adipose triglyceride lipase (ATGL) activity, has cardioprotective effects against catecholamine-induced cardiac damage in mice, according to a new study. Atglistatin inhibited adipose ATGL activity but had no effect on cardiac ATGL, indicating that its cardioprotective effects are mediated by non-cardiac actions.

Irene Fernández-Ruiz

Review Article | 04 October 2018

The role of adipose tissue in cardiovascular health and disease

This Review summarizes the current knowledge on the biology and regional variability of the adipose tissue, highlighting the molecular mechanisms controlling the crosstalk between the adipose tissue and the cardiovascular system. Current state-of-the-art techniques in adipose tissue imaging for cardiovascular risk stratification and the potential of the adipose tissue as a target for the treatment of cardiovascular disease are also described.