Cell–particle interactions articles within Nature Communications

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  • Article
    | Open Access

    Inorganic nanoparticles can accumulate in living organisms causing a dose-dependent increase in cellular reactive oxygen species. Here, the authors leverage this as a potential scheme for regulating metabolic disorders, showing that that low-dose nanoparticle administration can enhance lipid hydrolysis and alleviate fatty liver.

    • Jie Cai
    • , Jie Peng
    •  & Diming Wang

  • Article
    | Open Access

    Characterizing the soft protein corona on nanoparticles i.e. the outer layer of the corona, remains a longstanding challenge. Here, the authors develop an in situ method to monitor the dynamic processes of multilayered corona formation and evolution that offers a universal strategy to characterize the soft corona proteome.

    • Didar Baimanov
    • , Jing Wang
    •  & Chunying Chen

  • Article
    | Open Access

    Understanding the biological identity of nanoparticles has mainly focused on the hard protein corona with the soft corona largely overlooked. Here, using click-chemistry, the authors report on a capture system for the identification of the soft corona proteins and investigate the effects on cell interactions.

    • Hossein Mohammad-Beigi
    • , Yuya Hayashi
    •  & Duncan S. Sutherland

  • Article
    | Open Access

    The interaction between proteins and nanomaterials is complex and of interest for controlling nanoparticle fate. Here, using experimental and computational methods, the authors report on the effect of hydroxyl groups on protein interaction and how they can be used to enhance circulation times.

    • Xiang Lu
    • , Peipei Xu
    •  & Yu-Qiang Ma

  • Article
    | Open Access

    Cellular uptake of nanoparticles is highly variable between individual cells in a population. Here, the authors show that this heterogeneity is a result of varying numbers of nanoparticle-containing endosomes while the nanoparticle dose per endosome remains constant.

    • Paul Rees
    • , John W. Wills
    •  & Huw D. Summers

  • Article
    | Open Access

    Carbon-nanohorns have a unique morphology and structure yet little is known about the biocompatibility. Here, the authors investigate the biocompatibility and bio-interaction of carbon nanohorns, compare them to carbon nanotubes and show the superior biocompatibility and safety of the nanohorns.

    • Bing He
    • , Yujie Shi
    •  & Qiang Zhang

  • Article
    | Open Access

    Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easily internalized.

    • Peng Guo
    • , Daxing Liu
    •  & Marsha A. Moses

  • Article
    | Open Access

    The ability to spectroscopically pinpoint whether nanoparticles are located inside or outside of cells represents an overarching need in biology and medicine. Here, the authors show that the chirality of DNA-bridged particle dimers reverses when they cross the cell membrane, providing a real-time chiroptical signature of their intra- or extracellular location.

    • Maozhong Sun
    • , Liguang Xu
    •  & Chuanlai Xu

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