Cell invasion articles within Nature Communications

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  • Article
    | Open Access

    The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been associated with primary biliary cholangitis. Here, the authors demonstrate that CD8+ T cells invade BEC using a mechanism that is dependent on cytoskeletal rearrangements and E-cadherin:β-catenin interactions.

    • Scott P. Davies
    • , Vincenzo Ronca
    •  & Ye H. Oo

  • Article
    | Open Access

    Cancer cell motility is necessary for cell invasion and metastasis. Here, the authors identify CNK2 as a key mediator of cancer cell motility, linking extracellular stimuli via AXL signalling and downstream activation of ARF6 GTPase, resulting in increased metastasis in preclinical models.

    • Guillaume Serwe
    • , David Kachaner
    •  & Marc Therrien

  • Article
    | Open Access

    Plasmodium sporozoites actively migrate in the dermis and enter blood vessels to induce infection. Here, Formaglio et al. show that Plasmodium sporozoites alternate global superdiffusive skin exploration and local subdiffusive blood vessel exploitation to find intravasation hotspots associated with pericytes, enter the blood circulation and start malaria infection.

    • Pauline Formaglio
    • , Marina E. Wosniack
    •  & Rogerio Amino

  • Article
    | Open Access

    Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis.

    • Yuqi Zhang
    • , Yizeng Li
    •  & Konstantinos Konstantopoulos

  • Article
    | Open Access

    Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.

    • Florent Peglion
    • , Lavinia Capuana
    •  & Sandrine Etienne-Manneville

  • Article
    | Open Access

    Advanced glycation end products (AGEs) are believed to be pathogenic molecules that mediate pro-inflammatory responses. Here the authors identify histone as a cell-surface receptor for AGEs and show that AGEs may also be involved in the homeostatic response via binding to histone.

    • Masanori Itakura
    • , Kosuke Yamaguchi
    •  & Koji Uchida

  • Article
    | Open Access

    Changes in cell mechanics contribute to cancer cell dissemination. Here the authors show that high plasma membrane (PM) tension inhibits cancer dissemination by counteracting mechanosensitive BAR family protein assembly, while restoration of PM tension phenotypically convert malignant cells into a non-motile epithelial cell state.

    • Kazuya Tsujita
    • , Reiko Satow
    •  & Toshiki Itoh

  • Article
    | Open Access

    The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

    • Luca Di Leo
    • , Valérie Bodemeyer
    •  & Francesco Cecconi

  • Article
    | Open Access

    During development, primordial germ cell clusters undergo dispersal but how cell–cell adhesion and contractility are coordinated during this process in vivo is unclear. Here, the authors show that Drosophila primordial germ cells utilize migratory forces to disperse through G-protein coupled receptor mediated collective guidance of front-back polarity outwards from the cluster.

    • B. Lin
    • , J. Luo
    •  & R. Lehmann

  • Article
    | Open Access

    Drosophila tumours can be utilised to study the mechanisms of cell dissemination. Here, the authors use Drosophila midgut to examine the course of RasV12-transformed cell dissemination from midgut into circulation, which requires the actions of invasive protrusions and the mechanosensitive channel Piezo.

    • Jiae Lee
    • , Alejandra J. H. Cabrera
    •  & Young V. Kwon

  • Article
    | Open Access

    It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.

    • Irene Schiano Lomoriello
    • , Giovanni Giangreco
    •  & Pier Paolo Di Fiore

  • Article
    | Open Access

    Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Here, the authors show that RNF208, an estrogen-induced ubiquitin ligase, promotes the degradation of Vimentin, thereby suppressing lung metastasis of TNBC, and may serve as a biomarker for the disease.

    • Kyoungwha Pang
    • , Jinah Park
    •  & Seong-Jin Kim

  • Article
    | Open Access

    The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.

    • Robin Ferrari
    • , Gaëlle Martin
    •  & Philippe Chavrier

  • Article
    | Open Access

    Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models a NOTCH1 blocking antibody decreased spinal metastases.

    • Suzana A. Kahn
    • , Xin Wang
    •  & Samuel H. Cheshier

  • Article
    | Open Access

    In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can migrate through confining matrices using force generation alone, rather than protease degradation, if the matrices exhibit mechanical plasticity.

    • Katrina M. Wisdom
    • , Kolade Adebowale
    •  & Ovijit Chaudhuri

  • Article
    | Open Access

    Whilst estrogen is known to be tumorigenic in some breast cancer, in some contexts it can be protective against invasion and dissemination. Here, the authors show estrogen can promote generation of Suppressive Cortical Actin Bundles that can inhibit motility dynamics through EVL-mediated actin cytoskeletal remodeling.

    • Marco Padilla-Rodriguez
    • , Sara S. Parker
    •  & Ghassan Mouneimne

  • Article
    | Open Access

    Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production.

    • Yasuhito Onodera
    • , Jin-Min Nam
    •  & Hisataka Sabe

  • Article
    | Open Access

    In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.

    • Yael Nemlich
    • , Erez Nissim Baruch
    •  & Gal Markel

  • Article
    | Open Access

    Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.

    • Johannes Meiser
    • , Anne Schuster
    •  & Alexei Vazquez

  • Article
    | Open Access

    Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.

    • Emmanuel Dornier
    • , Nicolas Rabas
    •  & Jim C. Norman

  • Article
    | Open Access

    Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to form gaps.

    • Alexandros Glentis
    • , Philipp Oertle
    •  & Danijela Matic Vignjevic

  • Article
    | Open Access

    NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

    • Junyi Ju
    • , Aiping Chen
    •  & Quan Zhao

  • Article
    | Open Access

    Cell invasion is required for several physiological processes but it is unknown if stem cells induce invasiveness in other cells. Here, the authors show that human stem cells secrete insulin-like growth factor, which in turn activates the mTORC1 pathway, initiating invasive behaviour and attracting other cells.

    • Margit Rosner
    • , Ha Thi Thanh Pham
    •  & Markus Hengstschläger

  • Article
    | Open Access

    The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.

    • Juan R. Hernandez-Fernaud
    • , Elena Ruengeler
    •  & Sara Zanivan

  • Article
    | Open Access

    MicroRNAs represent potential therapeutic targets to control metastasis progression. Here the authors show that miR-96 and miR-182 regulate invasion via Palladin and demonstrate that local delivery of miR-96 and miR-182 may serve as a potential anti-metastatic drug in breast cancer.

    • Avital Gilam
    • , João Conde
    •  & Noam Shomron

  • Article
    | Open Access

    Plasmodium knowlesi infects macaques and can cause malaria in humans. Here, Dankwa et al. show that the absence of a sialic-acid component on the surface of macaque red blood cells (RBCs) limits infection of human RBCs with P. knowlesi, but the parasite can adapt to invade human RBCs by using alternative pathways.

    • Selasi Dankwa
    • , Caeul Lim
    •  & Manoj T. Duraisingh

  • Article
    | Open Access

    GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, can suppress the function of wild type GABRA3.

    • Kiranmai Gumireddy
    • , Anping Li
    •  & Qihong Huang

  • Article
    | Open Access

    The bacterium Bdellovibrio bacteriovorus invades and kills other bacteria, but it is unclear how it avoids degradation of its own cell wall. Here the authors identify the B. bacteriovorusprotein Bd3460 as an endopeptidase inhibitor that prevents hydrolysis of the predator’s peptidoglycan during invasion of prey.

    • Carey Lambert
    • , Ian T. Cadby
    •  & Andrew L. Lovering

  • Article |

    Cells shed various types of vesicles differing in size and content. Here the authors show that cancer cells utilize VAMP3-mediated traffic to deliver MT1-MMP to surface microvesicles and facilitate amoeboid-like cell invasion, with VAMP3-containing vesicles also found in body fluids of cancer patients.

    • James W. Clancy
    • , Alanna Sedgwick
    •  & Crislyn D’Souza-Schorey

  • Article |

    Histo-blood group antigens (HBGAs) have been proposed as essential cellular receptors for rotaviruses, which can cause severe diarrhoea in children. Here, the authors show that rotavirus strains display important variations in their ability to recognize different HBGAs.

    • Raphael Böhm
    • , Fiona E. Fleming
    •  & Thomas Haselhorst

  • Article |

    Phosphatidylinositol 5-phosphate (PtdIns5P) is known to induce actin depolymerisation and cell migration; however, the mechanisms by which this occurs remain unclear. Viaud et al.show that PtdIns5P regulates actin dynamics and invasiveness by recruiting and activating the Rac-GTPase exchange factor Tiam1.

    • Julien Viaud
    • , Frédéric Lagarrigue
    •  & Frédérique Gaits-Iacovoni

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