Catalytic DNA articles within Nature Communications

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• Comment
  17 June 2024 | Open Access

  The dynamic world of the 8–17 DNAzyme

  DNA catalysts, known as DNAzymes, have arguably been limited for decades by the lack of mechanistic information. The solution structure of the 8–17 DNAzyme reported by Wieruszekska, Pwlowicz et al. reassesses the current thinking regarding the relationship between structure, dynamic, and metal ion coordination.

  • Jessica Felice Schmuck
  • , Jan Borggräfe
  •  & Manuel Etzkorn

• Article
  17 May 2024 | Open Access

  The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor

  Here, the authors use solution-state NMR to characterize the structure of 8–17 DNAzyme, revealing that all metal cofactors induce the same DNAzyme fold in contrast to previous findings.

  • Julia Wieruszewska
  • , Aleksandra Pawłowicz
  •  & Witold Andrałojć

• Article
  16 November 2022 | Open Access

  XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection

  RNA viruses have been responsible for large-scale epidemics and pandemics throughout the last few centuries. Here, the authors show the design, synthesis and screening of artificial RNA endonuclease XNAzymes capable of cleaving genomic SARS-CoV-2 RNA and self-assembling into enzymatic nanostructures inhibiting cellular viral replication.

  • Pehuén Pereyra Gerber
  • , Maria J. Donde
  •  & Alexander I. Taylor

• Article
  18 January 2019 | Open Access

  Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions

  Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.

  • Hyunjin Jung
  • , Seong-Wook Kim
  •  & Won Do Heo