Cartilage development articles within Nature

Featured

• Article
  04 October 2023 | Open Access

  An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

  Haemoglobin produced by chondrocytes forms eosin-positive haemoglobin bodies in their cytoplasm, and deletion of these bodies causes severe hypoxia.

  • Feng Zhang
  • , Bo Zhang
  •  & Qiang Sun

• Article | 16 September 2020

  Evolution of the endothelin pathway drove neural crest cell diversification

  CRISPR–Cas9-mediated disruption of the endothelin-signalling pathway in the sea lamprey Petromyzon marinus and the frog Xenopus laevis were used to delineate ancient and lineage-specific roles of endothelin signalling and provide insights into vertebrate evolution.

  • Tyler A. Square
  • , David Jandzik
  •  & Daniel M. Medeiros

• Article | 26 February 2020

  Lipid availability determines fate of skeletal progenitor cells via SOX9

  Lipid starvation results in skeletal progenitors favouring commitment to chondrogenic over osteogenic fate, a process mediated by FOXO transcription factors and SOX9.

  • Nick van Gastel
  • , Steve Stegen
  •  & Geert Carmeliet

• Letter | 31 October 2018

  Resting zone of the growth plate houses a unique class of skeletal stem cells

  In a mouse model, PTHrP-positive chondrocytes in the resting zone of the growth plate constitute a unique stem-cell population, which is initially unipotent and makes columnar chondrocytes that later exhibit multipotency.

  • Koji Mizuhashi
  • , Wanida Ono
  •  & Noriaki Ono

• Letter | 25 April 2016

  The genetic program for cartilage development has deep homology within Bilateria

  Vertebrate and invertebrate cartilage share structural and biochemical properties, and their development is controlled by a highly conserved genetic circuit, suggesting that a deeply homologous mechanism underlies the parallel evolution of cartilage in Bilateria.

  • Oscar A. Tarazona
  • , Leslie A. Slota
  •  & Martin J. Cohn