Cardiology articles within Nature Communications

Featured

  • Article
    | Open Access

    5-hydroxymethylation of cysteine (5-hmC) plays a role in epigenetic regulation. Here the authors analyse the hydroxymethylome in embryonic, neonatal, adult and hypertrophic mouse cardiomyocytes and show that the dynamic modulation of hydroxymethylated DNA is important for cardiomyocyte gene expression programming in heart development and failure.

    • Carolina M. Greco
    • , Paolo Kunderfranco
    •  & Gianluigi Condorelli

  • Article
    | Open Access

    Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.

    • Mao Wang
    • , Patrick Sips
    •  & Stuart A Cook

  • Article
    | Open Access

    The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.

    • Bethany A. Kerr
    • , Xiaoxia Z. West
    •  & Tatiana V. Byzova

  • Article
    | Open Access

    Understanding coronary vessels development provides basis for regenerative strategies. Here, Soh et al. identify endothelin-1 as a key molecule driving long-term expansion of ISL1+bipotent vascular progenitors derived from human embryonic stem cells, and show that these cells can regenerate coronary vessels in mice.

    • Boon-Seng Soh
    • , Shi-Yan Ng
    •  & Kenneth R. Chien

  • Article
    | Open Access

    In myelinated fibres conduction and adhesion proteins aggregate at discrete foci, but it is unclear if this organization is present in other excitable cells. Using nanoscale visualization and in silico techniques, the authors show that adhesion/excitability nodes exist at the intercalated discs of adult cardiac muscle.

    • Alejandra Leo-Macias
    • , Esperanza Agullo-Pascual
    •  & Mario Delmar

  • Article |

    Mechanical and electrical activity in the heart is propagated through unique cardiomyocyte membrane structures, the intercalated discs (ID). Sharma et al.identify a novel ID protein, Tmem65, that controls Ca2+ signalling and electrical coupling by interacting with and functionally regulating the gap junction protein Cx43.

    • Parveen Sharma
    • , Cynthia Abbasi
    •  & Anthony O. Gramolini

  • Article
    | Open Access

    Adult cardiac progenitor/stem cells (CPSCs) possess valuable potential for heart repair that is limited by the elusiveness of these cells. Here Noseda et al. refine the definition of murine CPSCs producing stem cell antigen 1 (Sca1), mapping the cardiogenic signature and clonogenicity to the subgroup of Sca1+cells expressing PDGFRα.

    • Michela Noseda
    • , Mutsuo Harada
    •  & Michael D. Schneider

  • Article
    | Open Access

    The role of macrophages in hypertension-induced arterial remodeling is poorly understood. Here, Sumida et al. show that high blood pressure drives the alternatively activated macrophages to secrete complement C1q protein, which in turn elicits proliferative β-catenin signalling in the arterial smooth muscle cells.

    • Tomokazu Sumida
    • , Atsuhiko T. Naito
    •  & Issei Komuro

Browse broader subjects

Browse narrower subjects

Browse Cardiology across other nature.com journals