Cancer models

Cancer models are naturally existing or artificially induced systems that share features with human cancers. Experimental systems for studying human cancer include cell lines and organisms such as fruit flies and genetically modified mice to investigate cancer biochemical or genetic pathways and pathology.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Riva et al. exposed mice to a range of 20 known or suspected human carcinogens and then profiled the mutational signatures that arose in the tumours induced by them, finding that surprisingly the majority of the chemicals were not directly mutagenic.

    • Anna Dart
  • Research Highlights |

    Aitken et al. have used mutagen-induced liver tumours to trace individual strands of the DNA double helix to which damage occurred and correlate this with mutational patterns to inform upon tumour evolution.

    • Anna Dart
  • News & Views |

    Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

    • Sayan Chakraborty
    •  & Wanjin Hong
    Nature Materials 19, 707-709
  • News & Views |

    KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.

    • Luke A. Gilbert
    Nature Cancer 1, 575-576