Perspective
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Open Access
Featured
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Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer
- Kuo-Hsing Chen
- , Chia-Lang Hsu
- & Kun-Huei Yeh
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Article
| Open AccessIntegrative immune transcriptomic classification improves patient selection for precision immunotherapy in advanced gastro-oesophageal adenocarcinoma
- Manuel Cabeza-Segura
- , Valentina Gambardella
- & Tania Fleitas
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Comment |
Intratumour heterogeneity, from hypothesis to the clinic
- Naing Lin Shan
- , Adriana Kahn
- & Lajos Pusztai
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Article
| Open AccessFAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
- Catherine Davidson
- , David Taggart
- & Alan Serrels
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Article
| Open AccessSpatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
- Alphonse Charbel
- , Luca Tavernar
- & Benjamin Goeppert
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Article
| Open AccessIntratumoral PD-1+CD8+ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer
- Kuan Yu
- , Yun Gu
- & Jiejie Xu
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A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer
- Kaisa Cui
- , Surui Yao
- & Zhaohui Huang
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Article
| Open AccessLHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis
- Tao Xie
- , Kunpeng Du
- & Yawei Yuan
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Article
| Open AccessComprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk
- Mathilde M. Almekinders
- , Tycho Bismeijer
- & Alastair M. Thompson
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Article
| Open AccessModelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
- Guoying Zhou
- , Ruby Lieshout
- & Jaap Kwekkeboom
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HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway
- Kang Tang
- , Takeshi Toyozumi
- & Hisahiro Matsubara
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Article |
Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma
- Shiro Koizume
- , Tomoko Takahashi
- & Yohei Miyagi
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Article
| Open AccessPrognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
- Hanna Elomaa
- , Maarit Ahtiainen
- & Juha P. Väyrynen
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Article
| Open AccessA prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients
- Unn Beate Salberg
- , Vilde Eide Skingen
- & Heidi Lyng
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Perspective |
Cancer-inducing niche: the force of chronic inflammation
- Said M. Afify
- , Ghmkin Hassan
- & Masaharu Seno
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Editorial |
Elucidating the role of transiently hypoxic tumour cells on radiation resistance
- Geoff S. Higgins
- & Ester M. Hammond
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CD103+CD8+ tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer
- Kaifeng Jin
- , Yanze Yu
- & Zewei Wang
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TIGIT and PD-1 expression atlas predicts response to adjuvant chemotherapy and PD-L1 blockade in muscle-invasive bladder cancer
- Zhaopei Liu
- , Han Zeng
- & Zewei Wang
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Article |
Transiently hypoxic tumour cell turnover and radiation sensitivity in human tumour xenografts
- Brennan J. Wadsworth
- , Che-Min Lee
- & Kevin L. Bennewith
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Perspective |
Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?
- Claire Lugassy
- , Peter B. Vermeulen
- & Raymond L. Barnhill
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Article |
Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns
- Nouredin Messaoudi
- , David Henault
- & Simon Turcotte
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Article |
Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5
- Kosei Nakajima
- , Yoshinori Ino
- & Nobuyoshi Hiraoka
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Article |
Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting
- Daiki Ikarashi
- , Shigehisa Kitano
- & Wataru Obara
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Article |
High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model
- Pujarini Dash
- , Souvik Ghatak
- & Anita Sjölander
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TIM3+ cells in gastric cancer: clinical correlates and association with immune context
- Ke Chen
- , Yun Gu
- & Ruochen Li
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Review Article |
Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy
- Roseanna C. Wheatley
- , Elaine Kilgour
- & Mairéad G. McNamara
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Article |
Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma
- Chuan Lan
- , Yuki Kitano
- & Hideo Baba
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Review Article
| Open AccessThe gut microbiome: what the oncologist ought to know
- K. A. Lee
- , M. K. Luong
- & T. D. Spector
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Article |
The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis
- Juyong Liang
- , Zhijian Jin
- & Weihua Qiu
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Article
| Open AccessA deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma
- Amin Zadeh Shirazi
- , Mark D. McDonnell
- & Guillermo A. Gomez
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Review Article
| Open AccessTargeting obesity-related dysfunction in hormonally driven cancers
- Maria M. Rubinstein
- , Kristy A. Brown
- & Neil M. Iyengar
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Review Article |
The tumour immune microenvironment in oesophageal cancer
- Maria Davern
- , Noel E. Donlon
- & John V. Reynolds
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Review Article
| Open AccessVascular normalisation as the stepping stone into tumour microenvironment transformation
- Anette L. Magnussen
- & Ian G. Mills
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Article |
A Wnt-mediated phenotype switch along the epithelial–mesenchymal axis defines resistance and invasion downstream of ionising radiation in oral squamous cell carcinoma
- Fatemeh Zolghadr
- , Nigel Tse
- & Naisana Seyedasli
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Comment |
A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming
- Sin Chi Chew
- , Si Ying Choo
- & Pierce Kah-Hoe Chow
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Review Article
| Open AccessCancer metastasis as a non-healing wound
- Matthew Deyell
- , Christopher S. Garris
- & Ashley M. Laughney
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Article
| Open AccessTransitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study)
- Marc Oliva
- , Pierre H. H. Schneeberger
- & Anna Spreafico
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Comment
| Open AccessUnderstanding the impact of immune-mediated selection on lung cancer evolution
- Rachel Rosenthal
- , Charles Swanton
- & Nicholas McGranahan
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Article
| Open AccessPrognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)
- Hideki Ueno
- , Megumi Ishiguro
- & Kenichi Sugihara
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Correspondence
| Open AccessComment on “Identification of EMT-related high-risk stage II colorectal cancer and characterisation of metastasis-related genes”
- Maurice B. Loughrey
- , Natalie C. Fisher
- & Philip D. Dunne
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Article
| Open AccessTumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential
- Annasofia Anemone
- , Lorena Consolino
- & Dario Livio Longo
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Article
| Open AccessPrognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment
- Masayuki Shirasawa
- , Tatsuya Yoshida
- & Noriko Motoi
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Review Article
| Open AccessThe fibrotic and immune microenvironments as targetable drivers of metastasis
- Luke Boulter
- , Esme Bullock
- & Valerie G. Brunton
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Review Article
| Open AccessCysteine metabolic circuitries: druggable targets in cancer
- Vasco D. B. Bonifácio
- , Sofia A. Pereira
- & João B. Vicente
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Review Article
| Open AccessMetastasis: crosstalk between tissue mechanics and tumour cell plasticity
- Bircan Coban
- , Cecilia Bergonzini
- & Erik H. J. Danen
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Brief Communication
| Open AccessPlatelets enhance malignant behaviours of gastric cancer cells via direct contacts
- Ryo Saito
- , Katsutoshi Shoda
- & Daisuke Ichikawa
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Review Article
| Open AccessHypoxia and its therapeutic possibilities in paediatric cancers
- Carolina Bernauer
- , Y. K. Stella Man
- & Janet M. Shipley
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Review Article
| Open AccessCytotoxic CD8+ T cells in cancer and cancer immunotherapy
- Hans Raskov
- , Adile Orhan
- & Ismail Gögenur