Brief Communication
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Open Access
Featured
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Review Article
| Open AccessHypoxia and its therapeutic possibilities in paediatric cancers
- Carolina Bernauer
- , Y. K. Stella Man
- & Janet M. Shipley
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Review Article
| Open AccessCytotoxic CD8+ T cells in cancer and cancer immunotherapy
- Hans Raskov
- , Adile Orhan
- & Ismail Gögenur
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Article
| Open AccessEvidence for hypoxia increasing the tempo of evolution in glioblastoma
- David Robert Grimes
- , Marnix Jansen
- & David Basanta
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Editorial
| Open AccessBowel inflammation in cancer patients: the microbiome, antibiotics and interleukin-9
- Niels Halama
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Comment
| Open AccessT-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
- Christopher J. Hanley
- & Gareth J. Thomas
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Article
| Open AccessBacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study
- Michael Guenther
- , Michael Haas
- & Steffen Ormanns
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Article
| Open AccessTumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer
- Moran Yang
- , Guodong Zhang
- & Congjian Xu
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Article
| Open AccessSuppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease
- Michael B. Ware
- , Mohammad Y. Zaidi
- & Gregory B. Lesinski
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Correspondence
| Open AccessReply letter to comments on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis
- Zhihong Xu
- , Srinivasa Pothula
- & Minoti V. Apte
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Article
| Open AccessImmune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
- Stephanie G. Craig
- , Matthew P. Humphries
- & Manuel Salto-Tellez
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Article
| Open AccessImpacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model
- Yiannis Philippou
- , Hanna T. Sjoberg
- & Richard J. Bryant
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Article
| Open AccessEGFR/Ras-induced CCL20 production modulates the tumour microenvironment
- Andreas Hippe
- , Stephan Alexander Braun
- & Bernhard Homey
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Article
| Open AccessOestrogen receptor pathway activity is associated with outcome in endometrial cancer
- Willem Jan van Weelden
- , Louis J. M. van der Putten
- & Johanna M. A. Pijnenborg
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Article
| Open AccessOmental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2–VEGFA axis
- Makoto Natsume
- , Takaya Shimura
- & Hiromi Kataoka
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Article
| Open AccessEnrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis
- Diederik J. Höppener
- , Pieter M. H. Nierop
- & Cornelis Verhoef
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Article
| Open AccessKSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
- Maria Saveria Gilardini Montani
- , Luca Falcinelli
- & Mara Cirone
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Article
| Open AccessTumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas
- Malgorzata Sielska
- , Piotr Przanowski
- & Bozena Kaminska
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Article
| Open AccessMolecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma
- Fabien Robin
- , Gaëlle Angenard
- & Laurent Sulpice
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Review Article
| Open AccessEmerging role of PTEN loss in evasion of the immune response to tumours
- Thiago Vidotto
- , Camila Morais Melo
- & Jeremy A. Squire
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Article
| Open AccessDiagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma
- Maria Togo
- , Takehiko Yokobori
- & Tetsunari Oyama
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Article
| Open AccessMolecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response
- Min Hwan Kim
- , Jae-Hwan Kim
- & Hye Ryun Kim
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Article
| Open AccessImpairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells
- Ivana Kajanova
- , Miriam Zatovicova
- & Silvia Pastorekova
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Article
| Open AccessIdentification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
- Ruochen Li
- , Hao Liu
- & Jiejie Xu
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Article
| Open AccessTargeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis
- Zhihong Xu
- , Tony C. Y. Pang
- & Minoti V. Apte
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Article
| Open AccessAn integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer
- Koichiro Haruki
- , Keisuke Kosumi
- & Shuji Ogino
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Article
| Open AccessCarbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration
- Alexandra Giatromanolaki
- , Adrian L. Harris
- & Michael I. Koukourakis
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Review Article
| Open AccessCancer as a disease of old age: changing mutational and microenvironmental landscapes
- Ezio Laconi
- , Fabio Marongiu
- & James DeGregori
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Article
| Open AccessNintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts
- Takahiro Yamanaka
- , Norifumi Harimoto
- & Ken Shirabe
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Review Article
| Open AccessThe life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome
- Elisa D’Arcangelo
- , Nila C. Wu
- & Alison P. McGuigan
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Review Article
| Open AccessNew aspects of amino acid metabolism in cancer
- Lisa Vettore
- , Rebecca L. Westbrook
- & Daniel A. Tennant
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Article
| Open AccessProtein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1
- Sonam Kumari
- , Sheema Khan
- & Meena Jaggi
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Article
| Open AccessSpatial proximity between T and PD-L1 expressing cells as a prognostic biomarker for oropharyngeal squamous cell carcinoma
- Anna Maria Tsakiroglou
- , Martin Fergie
- & Catharine M. L. West
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Article
| Open AccessAssociation of the tumour stroma percentage in the preoperative biopsies with lymph node metastasis in colorectal cancer
- Meiting Fu
- , Dexin Chen
- & Side Liu
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Article
| Open AccessAssociation between the exposure to anti-angiogenic agents and tumour immune microenvironment in advanced gastrointestinal stromal tumours
- Changhoon Yoo
- , Yeon-mi Ryu
- & Yoon-Koo Kang
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Article
| Open AccessTumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages
- Qi Chen
- , Jianxin Wang
- & Xueli Bai
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Article
| Open AccessAberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion
- Wai Hoong Chang
- & Alvina G. Lai
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Article
| Open AccessMicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer
- Annesha Chatterjee
- , Samir Jana
- & Arindam Bhattacharyya
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Article
| Open AccessAcidity promotes tumour progression by altering macrophage phenotype in prostate cancer
- Asmaa El-Kenawi
- , Chandler Gatenbee
- & Robert Gillies
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Review Article
| Open AccessIn order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?
- Kym McNicholas
- , Melanie N. MacGregor
- & Jonathan M. Gleadle
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Editorial
| Open AccessMachine learning for tissue diagnostics in oncology: brave new world
- Niels Halama
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Review Article
| Open AccessCancer-associated fibroblasts—heroes or villains?
- Krystyna A. Gieniec
- , Lisa M. Butler
- & Susan L. Woods
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Article
| Open AccessNotch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry
- Mattia Capulli
- , Dayana Hristova
- & Anna Teti
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Article
| Open AccessTargeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy
- Magali Lecavalier-Barsoum
- , Naz Chaudary
- & Michael Milosevic
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Article
| Open AccessAnti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression
- Robert H. Berndsen
- , Cédric Castrogiovanni
- & Patrycja Nowak-Sliwinska
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Review Article
| Open AccessLipid metabolism in cancer cells under metabolic stress
- Rimsha Munir
- , Jan Lisec
- & Nousheen Zaidi
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Article
| Open AccessLow tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts
- Xiaowen Xu
- , Li Zhu
- & Fuao Cao
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Article
| Open AccessTumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA
- Bertrand Brassart
- , Jordan Da Silva
- & Sylvie Brassart-Pasco
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Article
| Open AccessInterferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma
- Hailong Ma
- , Wenyi Yang
- & Jingzhou Hu
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Review Article
| Open AccessThe clinical role of the TME in solid cancer
- Nicolas A. Giraldo
- , Rafael Sanchez-Salas
- & Catherine Sautès-Fridman