Featured
-
-
Article
| Open AccessEnhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition
- Seung Min Jeong
- , Sunsook Hwang
- & Rho Hyun Seong
-
Article
| Open AccessAutophagy is induced in the skeletal muscle of cachectic cancer patients
- Zaira Aversa
- , Fabrizio Pin
- & Maurizio Muscaritoli
-
Article
| Open AccessIdentification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma
- Sanne A. M. van Lith
- , Anna C. Navis
- & William P. J. Leenders
-
Article
| Open AccessMetabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway
- Ting Ma
- , Bo-Yi Fan
- & Ling-Yi Kong
-
Article
| Open AccessLipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma
- Kosuke Saito
- , Eri Arai
- & Yoshiro Saito
-
Article
| Open AccessMitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth
- D. M. Brown
- , H. Williams
- & T. Parr
-
Article
| Open AccessLeptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cells
- Wei-Hung Yang
- , An-Chen Chang
- & Chih-Hsin Tang
-
Article
| Open AccessThe space of enzyme regulation in HeLa cells can be inferred from its intracellular metabolome
- Christian Diener
- , Felipe Muñoz-Gonzalez
- & Osbaldo Resendis-Antonio
-
Article
| Open AccessTumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model
- Shan Xu
- , Yuan Tian
- & Huiru Tang
-
Article
| Open AccessComparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo
- Laura Brunelli
- , Elisa Caiola
- & Roberta Pastorelli
-
Article
| Open AccessSingle Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme
- Yu-Chih Chen
- , Yu-Heng Cheng
- & Euisik Yoon
-
Article
| Open AccessEffects of ADMA on gene expression and metabolism in serum-starved LoVo cells
- Ningning Zheng
- , Ke Wang
- & Houkai Li
-
Article
| Open AccessTherapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas
- Takahiro Isono
- , Tokuhiro Chano
- & Takeshi Yuasa
-
Article
| Open AccessIntegrated Droplet-Based Microextraction with ESI-MS for Removal of Matrix Interference in Single-Cell Analysis
- Xiao-Chao Zhang
- , Zhen-Wei Wei
- & Xin-Rong Zhang
-
Article
| Open AccessDiscovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt
- Cecilia Marini
- , Silvia Ravera
- & Gianmario Sambuceti
-
Article
| Open AccessPFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs
- Lili Chen
- , Jiajia Zhao
- & Chaodong Wu
-
Article
| Open AccessHepatitis B virus X protein (HBx)-induced abnormalities of nucleic acid metabolism revealed by 1H-NMR-based metabonomics
- Dan Yue
- , Yuwei Zhang
- & Ping Cheng
-
Article
| Open AccessCitrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma
- Aeyung Kim
- , Minju Im
- & Jin Yeul Ma
-
Article
| Open AccessMetabolic phenotyping for monitoring ovarian cancer patients
- Chaofu Ke
- , Ang Li
- & Kang Li
-
Article
| Open AccessRedox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells
- Pengying Li
- , Dongyang Zhang
- & Dongyun Shi
-
Article
| Open AccessNECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells
- Hiroki J. Nakaoka
- , Toshiro Hara
- & Takeharu Sakamoto
-
Article
| Open AccessInteraction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer
- Liangqian Huang
- , Zhenhai Yu
- & Gang Huang
-
Article
| Open AccessGlucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells
- Leonardo Venturelli
- , Silvia Nappini
- & Dan Cojoc
-
Article
| Open AccessRegulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions
- Shu-Hai Lin
- , Tengfei Liu
- & Zongwei Cai
-
Article
| Open AccessTissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer
- Yuan Tian
- , Tangpeng Xu
- & Huiru Tang
-
Article
| Open AccessPyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
- Chang-Liang He
- , Yang-Yang Bian
- & Wei Xu
-
Article
| Open AccessA Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
- Jun Koseki
- , Hidetoshi Matsui
- & Hideshi Ishii
-
Article
| Open AccessDivergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer
- Cecilia Marini
- , Giovanna Bianchi
- & Gianmario Sambuceti
-
Article
| Open AccessOxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation
- Gibok Lee
- , Hyung-Sik Won
- & Ji-Hong Lim
-
Article
| Open AccessDrug response in organoids generated from frozen primary tumor tissues
- Alex J. Walsh
- , Rebecca S. Cook
- & Melissa C. Skala
-
Article
| Open AccessThe pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia
- Matteo Allegretti
- , Maria Rosaria Ricciardi
- & Agostino Tafuri
-
Article
| Open AccessMetformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration
- Jiaojiao He
- , Ke Wang
- & Houkai Li
-
Article
| Open AccessNES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells
- Jiajia Hu
- , Hu Lei
- & Biao Li
-
Article
| Open AccessProline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides
- Wei Liu
- , Chad N. Hancock
- & James M. Phang
-
Article
| Open AccessMetabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells
- Emily G. Armitage
- , Helen L. Kotze
- & Kaye J. Williams
-
Article
| Open AccessIntegrative metabonomics as potential method for diagnosis of thyroid malignancy
- Yuan Tian
- , Xiu Nie
- & Yulan Wang
-
Article
| Open AccessThe folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
- Nina Gustafsson Sheppard
- , Lisa Jarl
- & Roland Nilsson
-
Article
| Open AccessElevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma
- Aritro Nath
- , Irene Li
- & Christina Chan
-
Article
| Open AccessDoxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer
- Wei-liang Ye
- , Yi-pu Zhao
- & Si-yuan Zhou
-
Article
| Open AccessIn situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry imaging
- Tiegang Li
- , Jiuming He
- & Zeper Abliz
-
Article
| Open AccessMetabolomic alterations in human cancer cells by vitamin C-induced oxidative stress
- Megumi Uetaki
- , Sho Tabata
- & Masaru Tomita
-
Article
| Open AccessHypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function
- Somayeh Jamali
- , Michael Klier
- & Holger M. Becker
-
Article
| Open AccessLarge scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer
- Xuefei Yin
- , Yang Zhang
- & Pengyuan Yang
-
Article
| Open AccessFlux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism
- Francesco Gatto
- , Heike Miess
- & Jens Nielsen
-
Article
| Open AccessNelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer
- Min Guan
- , Leila Su
- & Warren A. Chow
-
Article
| Open AccessPERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation
- Xu Hou
- , Yaohua Liu
- & Shiguang Zhao
-
Article
| Open AccessA weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
- Weijian Zhang
- , Lina Zhou
- & Guowang Xu
-
Article
| Open AccessOrgan-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms
- Kohei Taniguchi
- , Yuko Ito
- & Yukihiro Akao
-
Article
| Open AccessInhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain
- Jennifer Fazzari
- , Hanxin Lin
- & Gurmit Singh