Featured
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| Open AccessChemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.
- Raffaella Rossin
- , Ron M. Versteegen
- & Marc S. Robillard
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| Open AccessMotion model ultrasound localization microscopy for preclinical and clinical multiparametric tumor characterization
The vascular structure of tumors impacts diagnosis, prognosis and drug response; however, imaging methods to analyse this important feature have been hindered by spatial resolution limitations. Here the authors present a tool called motion model ultrasound localization microscopy to morphologically and functionally characterize fine vascular networks in tumors at super-resolution.
- Tatjana Opacic
- , Stefanie Dencks
- & Fabian Kiessling
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| Open AccessPharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibitor (IDH305) in 8 mutant IDH1 glioma patients.
- Ovidiu C. Andronesi
- , Isabel C. Arrillaga-Romany
- & Tracy T. Batchelor
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| Open AccessClinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice using broadly available tracers and imaging platforms.
- Nia Emami-Shahri
- , Julie Foster
- & Sophie Papa
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| Open AccessTargeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer
Molecular MRI is a powerful clinical tool for non-invasive detection of cancer biomarkers. Here, the authors develop a targeted peptide gadofullerene contrast agent that can sensitively distinguish between breast cancers of different aggressiveness.
- Zheng Han
- , Xiaohui Wu
- & Zheng-Rong Lu
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| Open AccessIn vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging
Background optical absorption of several biomolecules impedes an effective in vivo pH imaging in tumors. Here, the authors developed a visible light-based in vivo pH mapping method by coupling photoacoustic imaging and pH-responsive modified nanoparticles that selectively target tumor cells.
- Janggun Jo
- , Chang H. Lee
- & Xueding Wang
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Article
| Open AccessIn vivo cation exchange in quantum dots for tumor-specific imaging
The imaging of tumors in vivo using nanoprobes has been challenging due to the lack of sufficient tumor specificity. Here, the authors develop a tumor-specific quantum dot system that permits in vivo cation exchange to achieve selective background quenching and high tumor-specific imaging.
- Xiangyou Liu
- , Gary B. Braun
- & Kazuki N. Sugahara
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| Open AccessDynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators
Photoacoustic imaging becomes an enabling technology that is designed for clinic diagnosis of disease. Here, Chenet al. report an imaging contrast agent—plasmonic nanoparticles caged in hydrogel subject to reversible volume change depending on temperature, which exhibits tunable photoacoustic signal.
- Yun-Sheng Chen
- , Soon Joon Yoon
- & Stanislav Emelianov
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| Open AccessSynthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib
Lorlatinib—a ROS1/ALK inhibitor—is currently undergoing clinical trials for the treatment of non-small cell lung cancers. Here the authors develop synthetic routes to11C- and 18F-labelled lorlatinib, with subsequent PET imaging showing good blood brain barrier permeability in non-human primates.
- Thomas Lee Collier
- , Marc D. Normandin
- & Neil Vasdev
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| Open AccessImaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
Local pH alterations can be manifestations of pathologies such as cancer, inflammation and ischaemia. Here Düwelet al. show hyperpolarized 13C-labelled zymonic acid can be used as a non-invasive probe to map and measure pH in vivo, suggesting it as a candidate for clinical imaging and a diagnostic tool.
- Stephan Düwel
- , Christian Hundshammer
- & Franz Schilling
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| Open AccessHeterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.
- Michael F. Cuccarese
- , J. Matthew Dubach
- & Ralph Weissleder
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| Open AccessNon-invasive imaging using reporter genes altering cellular water permeability
Magnetic resonance imaging combined with molecular reporters can visualise cellular functions in intact organisms. Here Mukherjeeet al. present a cellular imaging approach based on intracellular changes in water diffusion using human aquaporin 1 gene as a genetically encoded reporter for MRI.
- Arnab Mukherjee
- , Di Wu
- & Mikhail G. Shapiro
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| Open AccessPredicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features
Diagnosis of lung cancer through manual histopathology evaluation is insufficient to predict patient survival. Here, the authors use computerized image processing to identify diagnostically relevant image features and use these features to distinguish lung cancer patients with different prognoses.
- Kun-Hsing Yu
- , Ce Zhang
- & Michael Snyder
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| Open AccessImaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish
Direct visualisation of heterogeneous cell populations in live animals has been challenging. Here, the authors optimize cell transplantation into optically clear immune-deficient zebrafish, and use intravital imaging to track and to assess functional diversity of individual cancer cells in vivo.
- Qin Tang
- , John C. Moore
- & David M. Langenau
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| Open AccessGram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications
Coordination polymers are promising drug delivery nanomaterials as their structural properties can be easily controlled. Here, Wang et al. prepare coordination nanodots that integrate cancer imaging and therapeutic functions with beneficial renal clearance.
- Fuyao Liu
- , Xiuxia He
- & Zhenxin Wang
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| Open AccessIn vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
Insufficient imaging sensitivity can make it challenging to assess early stage tumour lesions in vivo. Here, the authors present the radiopharmaceutical-excited fluorescence imaging technique that can detect tumour lesions less than 2 mm in size in living mice.
- Zhenhua Hu
- , Yawei Qu
- & Jie Tian
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Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo
As hypoxia is a hallmark of tumour microenvironment, hypoxia-sensing probes are used for tumour imaging. Here, the authors report a hypoxia probe with increased sensitivity, water solubility and functional pH range, allowing in vivodetection of early metastases as small as a few thousand cells.
- Xianchuang Zheng
- , Xin Wang
- & Xiqun Jiang
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| Open AccessDecoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
An individual tumour is often heterogeneous and its various features can be visualised noninvasively using medical imaging. Here, the authors analyse large computed tomography data sets using radiomic algorithms to identify heterogeneity, and find that some of these tumour features have prognostic value across cancer types.
- Hugo J. W. L. Aerts
- , Emmanuel Rios Velazquez
- & Philippe Lambin
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Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging
Fluorescence imaging in vivo is hampered by autofluorescence and the scattering and absorption of short-wavelength light. To address these problems, Xiong et al. produce self-luminescing nanoparticles that enable in vivonear-infrared imaging without external light excitation.
- Liqin Xiong
- , Adam J. Shuhendler
- & Jianghong Rao