Cancer epidemiology articles within Nature Communications

Featured

• Article
  06 February 2017 | Open Access

  Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

  Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

  • Philip J. Law
  • , Sonja I. Berndt
  •  & Susan Slager

• Article
  15 December 2015 | Open Access

  Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

  Smoking tobacco is known to alter DNA methylation. Here, the authors show that hypomethylation of smoke-related genes is associated with future increase in lung cancer risk.

  • Francesca Fasanelli
  • , Laura Baglietto
  •  & Paolo Vineis

• Article
  07 October 2015 | Open Access

  Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

  Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.

  • Meilin Wang
  • , Atsushi Takahashi
  •  & Jianfeng Xu

• Article | 07 July 2015

  Genome-wide association study of colorectal cancer identifies six new susceptibility loci

  Previous studies have shown that both rare pathogenic mutations and common genetic variants contribute to the familial risk of developing colorectal cancer. Here, the authors carry out a two-stage genome-wide association study and identify six new loci associated with colorectal cancer.

  • Fredrick R. Schumacher
  • , Stephanie L. Schmit
  •  & Ulrike Peters

• Article | 29 October 2014

  Variation in genomic landscape of clear cell renal cell carcinoma across Europe

  Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.

  • Ghislaine Scelo
  • , Yasser Riazalhosseini
  •  & G. Mark Lathrop

• Article | 08 August 2014

  Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

  Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and genetic susceptibility to the disease is poorly understood. Here, the authors combine data from Japanese, African American and European samples and identify a common variant in VTI1Athat increases CRC risk across all populations.

  • Hansong Wang
  • , Terrilea Burnett
  •  & Loïc Le Marchand