Calcium and phosphate metabolic disorders articles within Nature Communications

Featured

• Article
  21 March 2024 | Open Access

  Trimethylamine N-oxide impairs β-cell function and glucose tolerance

  β-Cell dysfunction is a hallmark of type 2 diabetes. Here, the authors show that trimethylamine N-oxide (TMAO (a microbiota metabolite)) induces β-cell dysfunction and type 2 diabetes in mice through NLRP3 inflammasome activation and calcium transients.

  • Lijuan Kong
  • , Qijin Zhao
  •  & Pingping Li

• Article
  08 July 2023 | Open Access

  The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase

  Hypophosphatasia (HPP) is a bone disease caused by mutations in tissue non-specific alkaline phosphatase (TNAP). Here, authors solved the crystal and cryoEM structures of TNAP, shedding light on the molecular mechanisms underlying HPP.

  • Yating Yu
  • , Kewei Rong
  •  & An Qin

• Article
  11 February 2023 | Open Access

  Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats

  How the liver mitochondria seamlessly regulate lipogenesis and lipid oxidation is unknown. Here, the authors report two functionally distinct populations of mitochondria, cytoplasmic and lipid droplet-associated mitochondria, and demonstrate that the latter’s lipid oxidation function is impaired in a rat NAFLD model.

  • Noble Kumar Talari
  • , Ushodaya Mattam
  •  & Naresh Babu V. Sepuri

• Article
  07 December 2020 | Open Access

  Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

  Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction between VDR and WBP4 blunting VDR signalling and normalizing calcium levels in vitamin D-intoxicated mice.

  • Daniela Rovito
  • , Anna Y. Belorusova
  •  & Daniel Metzger

• Article
  09 October 2020 | Open Access

  Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

  Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS

  • Hui J. Wang
  • , Chang Seok Lee
  •  & Susan L. Hamilton

• Article
  13 October 2017 | Open Access

  HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

  The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional activity of specific genes.

  • Jie Zheng
  • , Mi Ra Chang
  •  & Patrick R. Griffin