Bone development articles within Nature

Featured

  • Article |

    The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.

    • Seoyeon Bok
    • , Alisha R. Yallowitz
    •  & Matthew B. Greenblatt

  • Article |

    The rate of scale regeneration in zebrafish is controlled by the frequency of rhythmic travelling waves of Erk activity, which are broadcast from a central source to induce ring-like patterns of osteoblast tissue growth.

    • Alessandro De Simone
    • , Maya N. Evanitsky
    •  & Stefano Di Talia

  • Letter |

    Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.

    • Steve Stegen
    • , Kjell Laperre
    •  & Geert Carmeliet

  • Letter |

    During postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen, a process required for bone growth.

    • Laura Cinque
    • , Alison Forrester
    •  & Carmine Settembre

  • Article |

    Bone homeostasis and repair declines with ageing and the mechanisms regulating the relationship between bone growth and blood vessel formation have remained unknown; this mouse study identifies the endothelial cells that promote the formation of new bone, a small microvessel subtype that can be identified by high CD31 and high Emcn expression.

    • Anjali P. Kusumbe
    • , Saravana K. Ramasamy
    •  & Ralf H. Adams

  • News & Views |

    Because mammals have such high metabolic rates, it has long been thought that their growth is invulnerable to seasonal variation. But their bones turn out to contain annual lines, just as those of cold-blooded animals do. See Letter p.358

    • Kevin Padian

  • Article |

    Semaphorin 3A (Sema3A) is shown to function as a protector of bone, by synchronously inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation.

    • Mikihito Hayashi
    • , Tomoki Nakashima
    •  & Hiroshi Takayanagi

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