Bone cancer articles within Nature Medicine

Featured

• Letter | 21 January 2019

  Small-molecule targeting of brachyury transcription factor addiction in chordoma

  A combination of genome-scale CRISPR-Cas9 screening and focused small-molecule sensitivity profiling enables the discovery of therapeutically targetable tumor dependencies in rare tumors.

  • Tanaz Sharifnia
  • , Mathias J. Wawer
  •  & Stuart L. Schreiber

• Article | 15 January 2018

  Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

  Peter Scacheri and colleagues report that the activity of enhancer elements in metastatic osteosarcoma is distinct from that in primary tumors and plays a functional role in metastatic progression of osteosarcoma.

  • James J Morrow
  • , Ian Bayles
  •  & Peter C Scacheri