Bipolar disorder articles within Nature Communications

Featured

• Article
  03 November 2023 | Open Access

  Diurnal oscillations of MRI metrics in the brains of male participants

  Whether temporal variations in brain MRI metrics can be attributed to circadian or diurnal oscillations is unclear. Here, the authors show evidence for diurnal oscillations in MRI metrics in both healthy controls and participants with bipolar disorder.

  • Matthew Carlucci
  • , Tristram Lett
  •  & Art Petronis

• Article
  14 March 2023 | Open Access

  Regional clozapine, ECT and lithium usage inversely associated with excess suicide rates in male adolescents

  There are conflicting results on the effectiveness of pharmacologic interventions for suicide prevention in adolescence. Here, the authors show, in a retrospective registry study from Sweden during 2016–2020, that regional utilization rates of clozapine, electroconvulsive therapy and lithium in 15–19-year-olds were associated with lower excess suicide death rates in male adolescents

  • Adrian E. Desai Boström
  • , Peter Andersson
  •  & Jussi Jokinen

• Article
  18 June 2021 | Open Access

  Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder

  The significance of rare and de novo variants in bipolar disorder is not well understood. Here, the authors have analyzed whole exome/genome data from trios to identify deleterious de novo variants associated with bipolar disorder.

  • Masaki Nishioka
  • , An-a Kazuno
  •  & Atsushi Takata

• Article | 11 March 2014

  Genome-wide association study reveals two new risk loci for bipolar disorder

  Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

  • Thomas W. Mühleisen
  • , Markus Leber
  •  & Sven Cichon

• Article
  19 November 2013 | Open Access

  Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

  Schizophrenia and bipolar disorder are important psychiatric disorders with overlapping genetic components. Here, the authors identify and replicate a genome-wide significant risk locus for the two disorders, and suggest a role for NDST3in severe psychiatric disease.

  • Todd Lencz
  • , Saurav Guha
  •  & Ariel Darvasi

• Article | 08 January 2013

  A safe lithium mimetic for bipolar disorder

  Lithium is commonly used to treat bipolar disorder, but it exerts side effects at doses close to the therapeutic range. Singh and colleagues screen a collection of clinical compounds and find that ebselen induces lithium-like effects on mouse models of bipolar disorder by inhibiting inositol monophosphatase.

  • Nisha Singh
  • , Amy C. Halliday
  •  & Grant C. Churchill