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Phase separation organizes the site of autophagosome formation
The pre-autophagosomal structure in yeast is a liquid-like condensate of Atg proteins whose phase separation may have a critical, active role in autophagy.
- Yuko Fujioka
- , Jahangir Md. Alam
- & Nobuo N. Noda
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The mechanism of force transmission at bacterial focal adhesion complexes
The mystery of how bacteria that lack motile structures such as pili or flagella can ‘glide’ along surfaces is solved by a detailed description of the bacterial focal adhesion complex and its associated protein machinery.
- Laura M. Faure
- , Jean-Bernard Fiche
- & Tâm Mignot
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Letter |
Synthesis and applications of RNAs with position-selective labelling and mosaic composition
A hybrid solid–liquid phase transcription method and automated robotic platform synthesizes position-specific, fluorescence- or isotope-labelled RNA.
- Yu Liu
- , Erik Holmstrom
- & Yun-Xing Wang
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Letter |
Dynamic pathways of −1 translational frameshifting
To investigate the mechanism of frameshifting during messenger RNA translation, a technique was developed to monitor translation of single molecules in real time using Förster resonance energy transfer (FRET); ribosomes were revealed to pause tenfold longer than usual during elongation at the frameshifting sites.
- Jin Chen
- , Alexey Petrov
- & Joseph D. Puglisi
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Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
- Tim Grotjohann
- , Ilaria Testa
- & Stefan W. Hell
Nonlinear mechanics of human mitotic chromosomes