Barrett oesophagus articles within Nature Communications

Featured

• Article
  28 April 2022 | Open Access

  Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression

  Barrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find features associated with progressive disease.

  • Thomas G. Paulson
  • , Patricia C. Galipeau
  •  & Xiaohong Li

• Article
  17 March 2022 | Open Access

  Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity

  The alterations associated with progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma are not fully characterised. Here, the authors perform a multi-omics analysis of a longitudinally-sampled BE patient cohort, identifying the impact of structural variants, including mobile elements, and the timing of molecular events during progression.

  • A. C. Katz-Summercorn
  • , S. Jammula
  •  & R. C. Fitzgerald

• Article
  15 October 2018 | Open Access

  Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

  Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile that is similar to that of cells in oesophageal submucosal glands.

  • Richard Peter Owen
  • , Michael Joseph White
  •  & Xin Lu

• Article
  19 January 2016 | Open Access

  Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

  Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.

  • Yusuke Yamamoto
  • , Xia Wang
  •  & Wa Xian