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| Open AccessAn ester bond underlies the mechanical strength of a pathogen surface protein
Bacterial surface adhesion proteins are characterized by unusual mechanical properties. Here, the authors use atomic force microscopy-based technique to study a surface-anchoring protein Cpe0147 from Clostridium perfringens and show that an ester bond can withstand considerable mechanical forces and prevent complete protein unfolding.
- Hai Lei
- , Quan Ma
- & Yi Cao
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Article
| Open AccessDual functionality of the amyloid protein TasA in Bacillus physiology and fitness on the phylloplane
The amyloid protein TasA is a main component of the extracellular matrix in Bacillus subtilis biofilms. Here the authors show that, in addition to a structural function during biofilm assembly and interactions with plants, TasA contributes to the stabilization of membrane dynamics during stationary phase.
- Jesús Cámara-Almirón
- , Yurena Navarro
- & Diego Romero
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Article
| Open AccessCatch-bond mechanism of the bacterial adhesin FimH
Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.
- Maximilian M. Sauer
- , Roman P. Jakob
- & Rudi Glockshuber
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Article
| Open AccessStretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope
Bacteria express adhesive proteins on their surface that recognize fibronectin. Using a mechanical stretch assay and steered molecular dynamics, Chabriaet al. demonstrate that the binding of a bacterial adhesin to fibronectin is mechanoregulated, suggesting that bacteria can sense tissue fibre stretching.
- Mamta Chabria
- , Samuel Hertig
- & Viola Vogel