B-cell receptor articles within Nature

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• Article | 13 January 2021

  Loop extrusion mediates physiological Igh locus contraction for RAG scanning

  Long-distance V(D)J recombination is facilitated by contraction of the Igh locus and linear RAG scanning along chromatin, both driven by cohesin-mediated loop extrusion, which allows recombination of widely separated gene segments to occur.

  • Hai-Qiang Dai
  • , Hongli Hu
  •  & Frederick W. Alt

• Letter | 31 May 2017

  The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

  Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.

  • Gabriele Varano
  • , Simon Raffel
  •  & Stefano Casola

• Letter | 05 September 2010

  Oligomeric organization of the B-cell antigen receptor on resting cells

  B cells are activated by many different antigens to produce appropriate antibodies. B cells express up to 120,000 B-cell antigen receptor (BCR) complexes on their surface, but how do these complexes remain silent on resting B cells, and how are they activated? It is found here that the BCR on resting cells forms oligomers, and that these may be an autoinhibited form of the receptor. Disruption of the oligomer shifts B cells towards activation.

  • Jianying Yang
  •  & Michael Reth