Autoimmunity articles within Nature Communications

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• Article | 21 January 2014

  PTPN2 attenuates T-cell lymphopenia-induced proliferation

  Single nucleotide polymorphisms in the gene encoding the protein phosphatase PTPN2 are associated with autoimmunity in humans. Here, Wiede et al. show that PTPN2 suppresses the proliferative capacity of T cells in lymphopenia and prevents the development of autoimmunity resulting from overt homoeostatic proliferation.

  • Florian Wiede
  • , Nicole L. La Gruta
  •  & Tony Tiganis

• Article | 18 October 2013

  Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop

  Autoimmune T cell receptors can interact with both self and microbial antigens, but the structural basis for crossreactivity is not fully understood. Here, the authors provide structural insights into binding characteristics of the autoreactive T cell receptor Hy.1B11 to both self and pathogen-derived peptides.

  • Dhruv K. Sethi
  • , Susana Gordo
  •  & Kai W. Wucherpfennig