Atopic dermatitis

Atopic dermatitis, also known as atopic eczema, is a chronic inflammatory familial disease of the skin. It is characterized by an increased ability to form immunoglobulin E and a tendency to develop other allergic conditions such as allergic rhinitis and asthma.

Latest Research and Reviews

Research
16 November 2021 | Open Access

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Genetic studies of eczema to date have mostly explored common genetic variation. Here, the authors perform a large meta-analysis for common and rare variants and discover 8 loci associated with eczema. Over 20% of the heritability of the condition is attributable to rare variants.
- Sarah Grosche
- , Ingo Marenholz
- & Young-Ae Lee
Nature Communications 12, 6618
Research
23 June 2021 | Open Access

Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
- Weng Sheng Kong
- , Naohiro Tsuyama
- & Masamoto Kanno
Scientific Reports 11, 13109
Research
19 April 2021 | Open Access

The effects of antibiotic exposure on asthma in children with atopic dermatitis
- I-Lun Chen
- , Ming-Kai Tsai
- & Chih-Hsing Hung
Scientific Reports 11, 8526
Research
03 March 2021 | Open Access

Development of digital measures for nighttime scratch and sleep using wrist-worn wearable devices
- Nikhil Mahadevan
- , Yiorgos Christakis
- & Shyamal Patel
npj Digital Medicine 4, 42
Research | 22 February 2021

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

First-in-human test of topical application of a commensal bacterium on skin of individuals with atopic dermatitis reduces colonization by proinflammatory Staphylococcus aureus.
- Teruaki Nakatsuji
- , Tissa R. Hata
- & Richard L. Gallo
Nature Medicine 27, 700-709
Research
15 December 2020 | Open Access

Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
- Jenni Lehtimäki
- , Hanna Sinkko
- & Hannes Lohi
Scientific Reports 10, 21954

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News and Comment

Research Highlights | 14 May 2019

Skin microbiome relieves an itch

This study found that coagulase-negative staphylococci found on human skin inhibit Staphylococcus aureus quorum sensing and may influence the pathophysiology of S. aureus-associated atopic dermatitis.
- Ashley York
Nature Reviews Microbiology 17, 399
Comments & Opinion | 06 November 2017

The atopic dermatitis market

The market for atopic dermatitis therapies is dominated by topical corticosteroids, but is poised to change with the recent approvals of dupilumab and crisaborole, as well as other drugs in clinical development.
- Eleni Pantazi
- , Gianluca Valenza
- & Bashar Hamad
Nature Reviews Drug Discovery 17, 237-238
News | 08 September 2017

The evolving intellectual property landscape for pruritus therapies
- Benjamin Leung
- & Drew Lowery
Nature Reviews Drug Discovery 16, 670
News | 09 May 2017

First eczema biologic debuts but price could restrict use
- Elie Dolgin
Nature Biotechnology 35, 391-392
News & Views | 16 December 2016

Linking air pollution to atopic dermatitis

The relationship between atopic dermatitis and air pollution has been long debated but has now been connected via the aryl hydrocarbon receptor and its control of skin innervation and the consequent triggering of an itch-scratch response.
- Kenji Kabashima
- , Atsushi Otsuka
- & Takashi Nomura
Nature Immunology 18, 5-6
News | 30 August 2016

Galderma pursues 'itchy cytokine' by licensing antibody from Roche's Chugai
- Megan Cully
Nature Reviews Drug Discovery 15, 597

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Atopic dermatitis

Latest Research and Reviews

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s

The effects of antibiotic exposure on asthma in children with atopic dermatitis

Development of digital measures for nighttime scratch and sleep using wrist-worn wearable devices

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures

News and Comment

Skin microbiome relieves an itch

The atopic dermatitis market

The evolving intellectual property landscape for pruritus therapies

First eczema biologic debuts but price could restrict use

Linking air pollution to atopic dermatitis

Galderma pursues 'itchy cytokine' by licensing antibody from Roche's Chugai

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