Featured
-
-
Article
| Open Access
Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis
Inflammatory skin diseases are frequently associated with dysregulation of cutaneous immunity. Here the authors perform human challenge with house dust mite allergen in patients with atopic dermatitis and explore the molecular network determining tolerance versus inflammation and identify a role for metallothioneins in the modulation of allergen induced inflammation.
- Sofia Sirvent
- , Andres F. Vallejo
- & Marta E. Polak
-
Article
| Open Access
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Genetic studies of eczema to date have mostly explored common genetic variation. Here, the authors perform a large meta-analysis for common and rare variants and discover 8 loci associated with eczema. Over 20% of the heritability of the condition is attributable to rare variants.
- Sarah Grosche
- , Ingo Marenholz
- & Young-Ae Lee
-
Article
| Open Access
TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis
TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously into mice.
- Daniel Sidler
- , Ping Wu
- & Michael Croft
-
Article
| Open Access
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.
- Kazuhiko Yamamura
- , Takehito Uruno
- & Yoshinori Fukui
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis